Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii

Fumiaki Nakamura, Hiroshi Maejima, Midori Kawamura, Daisuke Arai, Tatsufumi Okino, Meng Zhao, Tao Ye, Jungyeol Lee, Young Tae Chang, Nobuhiro Fusetani, Yoichi Nakao

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Kakeromamide A (1), a new cyclic pentapeptide encompassing a thiazole ring moiety and a β-amino acid, was isolated from the marine cyanobacterium Moorea bouillonii. Its structure was elucidated by the spectral analysis and the modified Marfey's method. Compound 1 induced differentiation of neural stem cells into astrocytes at the concentration of 10 µM.

Original languageEnglish
Pages (from-to)2206-2209
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume28
Issue number12
DOIs
Publication statusPublished - 2018 Jul 1

Keywords

  • Astrocyte differentiation
  • Cyanobacterium
  • Marine natural products
  • Neural stem cells
  • Pentapeptide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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