Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii

Fumiaki Nakamura; Hiroshi Maejima; Midori Kawamura; Daisuke Arai; Tatsufumi Okino; Meng Zhao; Tao Ye; Jungyeol Lee; Young Tae Chang; Nobuhiro Fusetani; Yoichi Nakao

doi:10.1016/j.bmcl.2018.04.067

Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii

Fumiaki Nakamura, Hiroshi Maejima, Midori Kawamura, Daisuke Arai, Tatsufumi Okino, Meng Zhao, Tao Ye, Jungyeol Lee, Young Tae Chang, Nobuhiro Fusetani, Yoichi Nakao^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Kakeromamide A (1), a new cyclic pentapeptide encompassing a thiazole ring moiety and a β-amino acid, was isolated from the marine cyanobacterium Moorea bouillonii. Its structure was elucidated by the spectral analysis and the modified Marfey's method. Compound 1 induced differentiation of neural stem cells into astrocytes at the concentration of 10 µM.

Original language	English
Pages (from-to)	2206-2209
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	28
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2018.04.067
Publication status	Published - 2018 Jul 1

Keywords

Astrocyte differentiation
Cyanobacterium
Marine natural products
Neural stem cells
Pentapeptide

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2018.04.067

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Nakamura, F., Maejima, H., Kawamura, M., Arai, D., Okino, T., Zhao, M., Ye, T., Lee, J., Chang, Y. T., Fusetani, N., & Nakao, Y. (2018). Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii. Bioorganic and Medicinal Chemistry Letters, 28(12), 2206-2209. https://doi.org/10.1016/j.bmcl.2018.04.067

Nakamura, F, Maejima, H, Kawamura, M, Arai, D, Okino, T, Zhao, M, Ye, T, Lee, J, Chang, YT, Fusetani, N & Nakao, Y 2018, 'Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii', Bioorganic and Medicinal Chemistry Letters, vol. 28, no. 12, pp. 2206-2209. https://doi.org/10.1016/j.bmcl.2018.04.067

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abstract = "Kakeromamide A (1), a new cyclic pentapeptide encompassing a thiazole ring moiety and a β-amino acid, was isolated from the marine cyanobacterium Moorea bouillonii. Its structure was elucidated by the spectral analysis and the modified Marfey's method. Compound 1 induced differentiation of neural stem cells into astrocytes at the concentration of 10 µM.",

keywords = "Astrocyte differentiation, Cyanobacterium, Marine natural products, Neural stem cells, Pentapeptide",

author = "Fumiaki Nakamura and Hiroshi Maejima and Midori Kawamura and Daisuke Arai and Tatsufumi Okino and Meng Zhao and Tao Ye and Jungyeol Lee and Chang, {Young Tae} and Nobuhiro Fusetani and Yoichi Nakao",

note = "Funding Information: We appreciate Prof. K. Hori, Dr. M. Hirayama, and the crews of R/V Toyoshiomaru of Hiroshima University for their support in the sample collection. We are also thankful for Emeritus Prof. J. Kimura of Aoyama Gakuin University for providing synthetic samples of Amha. This paper is a part of the outcome of research performed under a Waseda University Grant-in-Aid for Scientific Research, the Strategic Research Platforms for Private University, a Matching Fund Subsidy from the Ministry of Education, Science, Sports, and Technology (MEXT), Japan, and JSPS KAKENHI Grant Numbers 26221204, 25303008, and 19310138; Shenzhen Peacock Plan (KQTD2015071714043444). This work was supported by JSPS Core-to-Core Program, A. Advanced Research Networks. This work was inspired by the international and interdisciplinary environments of the JSPS Asian CORE Program, Asian Chemical Biology Initiative (ACBI) and JSPS A3 Foresight Program. Publisher Copyright: {\textcopyright} 2018",

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doi = "10.1016/j.bmcl.2018.04.067",

language = "English",

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AU - Nakamura, Fumiaki

AU - Maejima, Hiroshi

AU - Kawamura, Midori

AU - Arai, Daisuke

AU - Okino, Tatsufumi

AU - Zhao, Meng

AU - Ye, Tao

AU - Lee, Jungyeol

AU - Chang, Young Tae

AU - Fusetani, Nobuhiro

AU - Nakao, Yoichi

N1 - Funding Information: We appreciate Prof. K. Hori, Dr. M. Hirayama, and the crews of R/V Toyoshiomaru of Hiroshima University for their support in the sample collection. We are also thankful for Emeritus Prof. J. Kimura of Aoyama Gakuin University for providing synthetic samples of Amha. This paper is a part of the outcome of research performed under a Waseda University Grant-in-Aid for Scientific Research, the Strategic Research Platforms for Private University, a Matching Fund Subsidy from the Ministry of Education, Science, Sports, and Technology (MEXT), Japan, and JSPS KAKENHI Grant Numbers 26221204, 25303008, and 19310138; Shenzhen Peacock Plan (KQTD2015071714043444). This work was supported by JSPS Core-to-Core Program, A. Advanced Research Networks. This work was inspired by the international and interdisciplinary environments of the JSPS Asian CORE Program, Asian Chemical Biology Initiative (ACBI) and JSPS A3 Foresight Program. Publisher Copyright: © 2018

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Kakeromamide A (1), a new cyclic pentapeptide encompassing a thiazole ring moiety and a β-amino acid, was isolated from the marine cyanobacterium Moorea bouillonii. Its structure was elucidated by the spectral analysis and the modified Marfey's method. Compound 1 induced differentiation of neural stem cells into astrocytes at the concentration of 10 µM.

AB - Kakeromamide A (1), a new cyclic pentapeptide encompassing a thiazole ring moiety and a β-amino acid, was isolated from the marine cyanobacterium Moorea bouillonii. Its structure was elucidated by the spectral analysis and the modified Marfey's method. Compound 1 induced differentiation of neural stem cells into astrocytes at the concentration of 10 µM.

KW - Astrocyte differentiation

KW - Cyanobacterium

KW - Marine natural products

KW - Neural stem cells

KW - Pentapeptide

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ER -

Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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