Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii

Fumiaki Nakamura, Hiroshi Maejima, Midori Kawamura, Daisuke Arai, Tatsufumi Okino, Meng Zhao, Tao Ye, Jungyeol Lee, Young Tae Chang, Nobuhiro Fusetani, Youichi Nakao

Research output: Contribution to journalArticle

Abstract

Kakeromamide A (1), a new cyclic pentapeptide encompassing a thiazole ring moiety and a β-amino acid, was isolated from the marine cyanobacterium Moorea bouillonii. Its structure was elucidated by the spectral analysis and the modified Marfey's method. Compound 1 induced differentiation of neural stem cells into astrocytes at the concentration of 10 µM.

Original languageEnglish
JournalBioorganic and Medicinal Chemistry Letters
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Fingerprint

Thiazoles
Neural Stem Cells
Cyanobacteria
Stem cells
Astrocytes
Spectrum analysis
Amino Acids

Keywords

  • Astrocyte differentiation
  • Cyanobacterium
  • Marine natural products
  • Neural stem cells
  • Pentapeptide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii. / Nakamura, Fumiaki; Maejima, Hiroshi; Kawamura, Midori; Arai, Daisuke; Okino, Tatsufumi; Zhao, Meng; Ye, Tao; Lee, Jungyeol; Chang, Young Tae; Fusetani, Nobuhiro; Nakao, Youichi.

In: Bioorganic and Medicinal Chemistry Letters, 01.01.2018.

Research output: Contribution to journalArticle

Nakamura, Fumiaki ; Maejima, Hiroshi ; Kawamura, Midori ; Arai, Daisuke ; Okino, Tatsufumi ; Zhao, Meng ; Ye, Tao ; Lee, Jungyeol ; Chang, Young Tae ; Fusetani, Nobuhiro ; Nakao, Youichi. / Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii. In: Bioorganic and Medicinal Chemistry Letters. 2018.
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AU - Okino, Tatsufumi

AU - Zhao, Meng

AU - Ye, Tao

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