Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa

Youichi Nakao, Wesley Y. Yoshida, Yuuki Takada, Junji Kimura, Liu Yang, Susan L. Mooberry, Paul J. Scheuer

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.

Original languageEnglish
Pages (from-to)1332-1340
Number of pages9
JournalJournal of Natural Products
Volume67
Issue number8
DOIs
Publication statusPublished - 2004 Aug
Externally publishedYes

Fingerprint

depsipeptides
Depsipeptides
chemical degradation
Mollusca
molluscs
inhibitory concentration 50
cytotoxicity
cell lines
Cells
Spectroscopic analysis
antineoplaston A10
Cytotoxicity
Inhibitory Concentration 50
Cell Line
Degradation
neoplasm cells
kulokekahilide-2
Neoplasms

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Nakao, Y., Yoshida, W. Y., Takada, Y., Kimura, J., Yang, L., Mooberry, S. L., & Scheuer, P. J. (2004). Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa. Journal of Natural Products, 67(8), 1332-1340. https://doi.org/10.1021/np049949f

Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa. / Nakao, Youichi; Yoshida, Wesley Y.; Takada, Yuuki; Kimura, Junji; Yang, Liu; Mooberry, Susan L.; Scheuer, Paul J.

In: Journal of Natural Products, Vol. 67, No. 8, 08.2004, p. 1332-1340.

Research output: Contribution to journalArticle

Nakao, Y, Yoshida, WY, Takada, Y, Kimura, J, Yang, L, Mooberry, SL & Scheuer, PJ 2004, 'Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa', Journal of Natural Products, vol. 67, no. 8, pp. 1332-1340. https://doi.org/10.1021/np049949f
Nakao, Youichi ; Yoshida, Wesley Y. ; Takada, Yuuki ; Kimura, Junji ; Yang, Liu ; Mooberry, Susan L. ; Scheuer, Paul J. / Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa. In: Journal of Natural Products. 2004 ; Vol. 67, No. 8. pp. 1332-1340.
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