Abstract
We have developed a field effect transistor (FET) sensor to sensitively detect copper ions (Cu<sup>2+</sup>) in a human serum (HS) sample for promising health-care diagnosis. By utilizing a Cu<sup>2+</sup>-binding prion protein that was immobilized on the FET gate surface, such an FET sensor can provide a simple, label free and highly selective performance, even in HS samples. We demonstrated the sensitivity of the sensor at the nanomolar level, 0-100 nM, which is very useful for the detection range of Cu<sup>2+</sup> deficiency in practical applications.
| Original language | English |
|---|---|
| Pages (from-to) | 6485-6488 |
| Number of pages | 4 |
| Journal | Analyst |
| Volume | 140 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 2015 Oct 7 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Spectroscopy
- Electrochemistry
- Biochemistry
- Environmental Chemistry
Cite this
Label-free detection of Cu(II) in a human serum sample by using a prion protein-immobilized FET sensor. / Wustoni, Shofarul; Hideshima, Sho; Kuroiwa, Shigeki; Nakanishi, Takuya; Mori, Yasuro; Osaka, Tetsuya.
In: Analyst, Vol. 140, No. 19, 07.10.2015, p. 6485-6488.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Label-free detection of Cu(II) in a human serum sample by using a prion protein-immobilized FET sensor
AU - Wustoni, Shofarul
AU - Hideshima, Sho
AU - Kuroiwa, Shigeki
AU - Nakanishi, Takuya
AU - Mori, Yasuro
AU - Osaka, Tetsuya
PY - 2015/10/7
Y1 - 2015/10/7
N2 - We have developed a field effect transistor (FET) sensor to sensitively detect copper ions (Cu2+) in a human serum (HS) sample for promising health-care diagnosis. By utilizing a Cu2+-binding prion protein that was immobilized on the FET gate surface, such an FET sensor can provide a simple, label free and highly selective performance, even in HS samples. We demonstrated the sensitivity of the sensor at the nanomolar level, 0-100 nM, which is very useful for the detection range of Cu2+ deficiency in practical applications.
AB - We have developed a field effect transistor (FET) sensor to sensitively detect copper ions (Cu2+) in a human serum (HS) sample for promising health-care diagnosis. By utilizing a Cu2+-binding prion protein that was immobilized on the FET gate surface, such an FET sensor can provide a simple, label free and highly selective performance, even in HS samples. We demonstrated the sensitivity of the sensor at the nanomolar level, 0-100 nM, which is very useful for the detection range of Cu2+ deficiency in practical applications.
UR - http://www.scopus.com/inward/record.url?scp=84941654110&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941654110&partnerID=8YFLogxK
U2 - 10.1039/c5an01115a
DO - 10.1039/c5an01115a
M3 - Article
VL - 140
SP - 6485
EP - 6488
JO - The Analyst
JF - The Analyst
SN - 0003-2654
IS - 19
ER -