Label-free detection of Cu(II) in a human serum sample by using a prion protein-immobilized FET sensor

Shofarul Wustoni, Sho Hideshima, Shigeki Kuroiwa, Takuya Nakanishi, Yasuro Mori, Tetsuya Osaka

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

We have developed a field effect transistor (FET) sensor to sensitively detect copper ions (Cu2+) in a human serum (HS) sample for promising health-care diagnosis. By utilizing a Cu2+-binding prion protein that was immobilized on the FET gate surface, such an FET sensor can provide a simple, label free and highly selective performance, even in HS samples. We demonstrated the sensitivity of the sensor at the nanomolar level, 0-100 nM, which is very useful for the detection range of Cu2+ deficiency in practical applications.

Original languageEnglish
Pages (from-to)6485-6488
Number of pages4
JournalAnalyst
Volume140
Issue number19
DOIs
Publication statusPublished - 2015 Oct 7

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

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