Lack of age-related increase in carotid artery wall viscosity in cardiorespiratory fit men

Hiroshi Kawano, Kenta Yamamoto, Yuko Gando, Michiya Tanimoto, Haruka Murakami, Yumi Ohmori, Kiyoshi Sanada, Izumi Tabata, Mitsuru Higuchi, Motohiko Miyachi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVES:: Age-related arterial stiffening and reduction of arterial elasticity are attenuated in individuals with high levels of cardiorespiratory fitness. Viscosity is another mechanical characteristic of the arterial wall; however, the effects of age and cardiorespiratory fitness have not been determined. We examined the associations among age, cardiorespiratory fitness and carotid arterial wall viscosity. METHODS:: A total of 111 healthy men, aged 25-39 years (young) and 40-64 years (middle-aged), were divided into either cardiorespiratory fit or unfit groups on the basis of peak oxygen uptake. The common carotid artery was measured noninvasively by tonometry and automatic tracking of B-mode images to obtain instantaneous pressure and diameter hysteresis loops, and we calculated the effective compliance, isobaric compliance and viscosity index. RESULTS:: In the middle-aged men, the viscosity index was larger in the unfit group than in the fit group (2533 vs. 2018âmmHg·s/mm, respectively: Pâ Š0.05), but this was not the case in the young men. In addition, effective and isobaric compliance were increased, and viscosity index was increased with advancing age, but these parameters were unaffected by cardiorespiratory fitness level. CONCLUSION:: These results suggest that the wall viscosity in the central artery is increased with advancing age and that the age-associated increase in wall viscosity may be attenuated in cardiorespiratory fit men.

Original languageEnglish
Pages (from-to)2370-2379
Number of pages10
JournalJournal of Hypertension
Volume31
Issue number12
DOIs
Publication statusPublished - 2013 Dec
Externally publishedYes

Fingerprint

Carotid Arteries
Viscosity
Compliance
Common Carotid Artery
Manometry
Elasticity
Arteries
Oxygen
Pressure
Cardiorespiratory Fitness

Keywords

  • ageing, arterial compliance
  • arterial viscoelasticity
  • cardiopulmonary fitness
  • exercise

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Kawano, H., Yamamoto, K., Gando, Y., Tanimoto, M., Murakami, H., Ohmori, Y., ... Miyachi, M. (2013). Lack of age-related increase in carotid artery wall viscosity in cardiorespiratory fit men. Journal of Hypertension, 31(12), 2370-2379. https://doi.org/10.1097/HJH.0b013e328364cbba

Lack of age-related increase in carotid artery wall viscosity in cardiorespiratory fit men. / Kawano, Hiroshi; Yamamoto, Kenta; Gando, Yuko; Tanimoto, Michiya; Murakami, Haruka; Ohmori, Yumi; Sanada, Kiyoshi; Tabata, Izumi; Higuchi, Mitsuru; Miyachi, Motohiko.

In: Journal of Hypertension, Vol. 31, No. 12, 12.2013, p. 2370-2379.

Research output: Contribution to journalArticle

Kawano, H, Yamamoto, K, Gando, Y, Tanimoto, M, Murakami, H, Ohmori, Y, Sanada, K, Tabata, I, Higuchi, M & Miyachi, M 2013, 'Lack of age-related increase in carotid artery wall viscosity in cardiorespiratory fit men', Journal of Hypertension, vol. 31, no. 12, pp. 2370-2379. https://doi.org/10.1097/HJH.0b013e328364cbba
Kawano, Hiroshi ; Yamamoto, Kenta ; Gando, Yuko ; Tanimoto, Michiya ; Murakami, Haruka ; Ohmori, Yumi ; Sanada, Kiyoshi ; Tabata, Izumi ; Higuchi, Mitsuru ; Miyachi, Motohiko. / Lack of age-related increase in carotid artery wall viscosity in cardiorespiratory fit men. In: Journal of Hypertension. 2013 ; Vol. 31, No. 12. pp. 2370-2379.
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AU - Yamamoto, Kenta

AU - Gando, Yuko

AU - Tanimoto, Michiya

AU - Murakami, Haruka

AU - Ohmori, Yumi

AU - Sanada, Kiyoshi

AU - Tabata, Izumi

AU - Higuchi, Mitsuru

AU - Miyachi, Motohiko

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N2 - OBJECTIVES:: Age-related arterial stiffening and reduction of arterial elasticity are attenuated in individuals with high levels of cardiorespiratory fitness. Viscosity is another mechanical characteristic of the arterial wall; however, the effects of age and cardiorespiratory fitness have not been determined. We examined the associations among age, cardiorespiratory fitness and carotid arterial wall viscosity. METHODS:: A total of 111 healthy men, aged 25-39 years (young) and 40-64 years (middle-aged), were divided into either cardiorespiratory fit or unfit groups on the basis of peak oxygen uptake. The common carotid artery was measured noninvasively by tonometry and automatic tracking of B-mode images to obtain instantaneous pressure and diameter hysteresis loops, and we calculated the effective compliance, isobaric compliance and viscosity index. RESULTS:: In the middle-aged men, the viscosity index was larger in the unfit group than in the fit group (2533 vs. 2018âmmHg·s/mm, respectively: Pâ Š0.05), but this was not the case in the young men. In addition, effective and isobaric compliance were increased, and viscosity index was increased with advancing age, but these parameters were unaffected by cardiorespiratory fitness level. CONCLUSION:: These results suggest that the wall viscosity in the central artery is increased with advancing age and that the age-associated increase in wall viscosity may be attenuated in cardiorespiratory fit men.

AB - OBJECTIVES:: Age-related arterial stiffening and reduction of arterial elasticity are attenuated in individuals with high levels of cardiorespiratory fitness. Viscosity is another mechanical characteristic of the arterial wall; however, the effects of age and cardiorespiratory fitness have not been determined. We examined the associations among age, cardiorespiratory fitness and carotid arterial wall viscosity. METHODS:: A total of 111 healthy men, aged 25-39 years (young) and 40-64 years (middle-aged), were divided into either cardiorespiratory fit or unfit groups on the basis of peak oxygen uptake. The common carotid artery was measured noninvasively by tonometry and automatic tracking of B-mode images to obtain instantaneous pressure and diameter hysteresis loops, and we calculated the effective compliance, isobaric compliance and viscosity index. RESULTS:: In the middle-aged men, the viscosity index was larger in the unfit group than in the fit group (2533 vs. 2018âmmHg·s/mm, respectively: Pâ Š0.05), but this was not the case in the young men. In addition, effective and isobaric compliance were increased, and viscosity index was increased with advancing age, but these parameters were unaffected by cardiorespiratory fitness level. CONCLUSION:: These results suggest that the wall viscosity in the central artery is increased with advancing age and that the age-associated increase in wall viscosity may be attenuated in cardiorespiratory fit men.

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