Lactate Metabolism and Satellite Cell Fate

Minas Nalbandian, Zsolt Radak, Masaki Takeda

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Lactate is one of the metabolic products of glycolysis. It is widely accepted as an important energy source for many cell types and more recently has been proposed to actively participate in cell-cell communication. Satellite cells (SCs), which are adult skeletal muscle stem cells, are the main players of the skeletal muscle regeneration process. Recent studies have proposed a metabolic switch to increase glycolysis in activated SCs. Moreover, lactate has been shown to affect SCs and myoblasts in vivo and in vitro. In this short review, we describe how metabolic variations relate with SC fate (quiescence, activation, proliferation, migration, differentiation, fusion, and self-renewal), as well as discuss possible relationships between lactate as a metabolite and as a signaling molecule affecting SC fate.

Original languageEnglish
Article number610983
JournalFrontiers in Physiology
Volume11
DOIs
Publication statusPublished - 2020 Dec 11
Externally publishedYes

Keywords

  • lactate
  • metabolism
  • muscle regeneration
  • muscle stem cell
  • skeletal muscle

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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