Lactotripeptide ingestion increases cerebral blood flow velocity in middle-aged and older adults

Nobuhiko Akazawa, Ai Hamasaki, Koichiro Tanahashi, Keisei Kosaki, Toru Yoshikawa, Kanae Myoenzono, Seiji Maeda*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The age-related decrease in cerebral blood flow velocity increases the risk of cerebrovascular disease. Milk protein-derived bioactive peptides, e.g., lactotripeptide (LTP), have been shown to inhibit angiotensin converting enzyme activities and increase vasodilator production. We hypothesized that LTP ingestion increases cerebral blood flow velocity in middle-aged and older adults. In a randomized, placebo-controlled, double-blind design, 15 healthy middle-aged and older adults were assigned to either a LTP group or a placebo group. The subjects ingested LTP or placebo orally for 8 weeks. Before and after intervention, middle cerebral blood flow velocity was measured using transcranial Doppler ultrasonography. The baseline middle cerebral blood flow velocity and most other key dependent variables did not differ between the groups. LTP ingestion significantly increased middle cerebral blood flow velocity, but there was no such improvement in the placebo groups. We concluded that 8 weeks of LTP ingestion increased middle cerebral blood flow velocity in middle-aged and older adults.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalNutrition Research
Volume53
DOIs
Publication statusPublished - 2018 May
Externally publishedYes

Keywords

  • Aging
  • Casein hydrolysate
  • Cerebral hemodynamics
  • Executive function
  • Milk peptides

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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