Lanthanide metal complexes for the hydrolysis of linear DNAs

Tetsuro Shiiba, Koji Yonezawa, Naoya Takeda, Yoichi Matsumoto, Morio Yashiro, Makoto Komiyama

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Lanthanum (III) and cerium (III) complexes of macrocyclic ligands efficiently hydrolyze the phosphodiester linkages in linear DNAs at pH 7.2 and 30-50°C. Both single-stranded and double-stranded DNAs are hydrolysed without specific base preference, yielding predominantly 3′-phosphate termini. The potential of these complexes as the catalytic centers of artificial hydrolytic nucleases are indicated.

Original languageEnglish
JournalJournal of Molecular Catalysis
Volume84
Issue number1
DOIs
Publication statusPublished - 1993 Sep 21
Externally publishedYes

Fingerprint

Metal complexes
Rare earth elements
Hydrolysis
DNA
Lanthanum
Cerium
Phosphates
Ligands

Keywords

  • artificial nuclease
  • cerium (III) complex
  • DNA hydrolysis
  • lanthanide (III) complex
  • lanthanum (III) complex

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Lanthanide metal complexes for the hydrolysis of linear DNAs. / Shiiba, Tetsuro; Yonezawa, Koji; Takeda, Naoya; Matsumoto, Yoichi; Yashiro, Morio; Komiyama, Makoto.

In: Journal of Molecular Catalysis, Vol. 84, No. 1, 21.09.1993.

Research output: Contribution to journalArticle

Shiiba, Tetsuro ; Yonezawa, Koji ; Takeda, Naoya ; Matsumoto, Yoichi ; Yashiro, Morio ; Komiyama, Makoto. / Lanthanide metal complexes for the hydrolysis of linear DNAs. In: Journal of Molecular Catalysis. 1993 ; Vol. 84, No. 1.
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AU - Komiyama, Makoto

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