Large three-dimensional mesocage pores tailoring silica nanotubes as membrane filters: Nanofiltration and permeation flux of proteins

Sherif El-Safty, Ahmed Shahat, Md Rabiul Awual, Moataz Mekawy

    Research output: Contribution to journalArticle

    92 Citations (Scopus)

    Abstract

    Large three-dimensional (3D) mesocage structures that have multidirectional pore networks and uniform openings perpendicular to the longitudinal axis of NTs are of particular interest in terms of their potential. This paper reports on the feasibility of direct control of 3D mesopore cage structures throughout silica nanotubes (NTs) vertically aligned inside Anodic Alumina Membrane (AAM) nanochannels without the use of any organic stabilizing modifiers. This is the first reported study which uses direct synthesis of ordered cubic Im3m mesocage structures inside well-aligned silica-NTs that have open surfaces of top-bottom ends, and multidirectional (3D) mesopore connectivity. These 3D mesocage silica-NT arrays hybrid AAM channels function as nanofilters that can rapidly (in seconds) separate large quantities of proteins. In this nanofiltration assay, three proteins that differ in molecular weight and size such as cytochrome c (CytC), myoglobin (Mb), and hemoglobin (Hb) were used. The prominent factors affecting nanofiltration and permeation flux performance of nanoscale cage membranes are: (i) the concentration of the feed solution of protein (retentate), (ii) molecular sizes and weights of proteins, and (iii) stability of the hierarchical mesocage structures during the filtration and permeation processes. Although the protein nanofiltration efficiency decreased during the reuse cycles of the nanofilter membranes, the proposed nanofilters still exhibited well-controlled molecular-size cut-off after a number of cycles. These mesocage silica-NT-supported membranes are expected to be promising for the development of new generation high-precision, uniform-porosity, and bio-compatible nanofilters with molecular-size cut-off systems.

    Original languageEnglish
    Pages (from-to)5593-5603
    Number of pages11
    JournalJournal of Materials Chemistry
    Volume21
    Issue number15
    DOIs
    Publication statusPublished - 2011 Apr 21

    Fingerprint

    Nanofiltration
    Permeation
    Silicon Dioxide
    Nanotubes
    Silica
    Fluxes
    Proteins
    Membranes
    Aluminum Oxide
    Alumina
    Myoglobin
    Cytochromes c
    Ion Channels
    Hemoglobin
    Assays
    Hemoglobins
    Porosity
    Molecular weight

    ASJC Scopus subject areas

    • Materials Chemistry
    • Chemistry(all)

    Cite this

    Large three-dimensional mesocage pores tailoring silica nanotubes as membrane filters : Nanofiltration and permeation flux of proteins. / El-Safty, Sherif; Shahat, Ahmed; Awual, Md Rabiul; Mekawy, Moataz.

    In: Journal of Materials Chemistry, Vol. 21, No. 15, 21.04.2011, p. 5593-5603.

    Research output: Contribution to journalArticle

    El-Safty, Sherif ; Shahat, Ahmed ; Awual, Md Rabiul ; Mekawy, Moataz. / Large three-dimensional mesocage pores tailoring silica nanotubes as membrane filters : Nanofiltration and permeation flux of proteins. In: Journal of Materials Chemistry. 2011 ; Vol. 21, No. 15. pp. 5593-5603.
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