Learning behavior in rat offspring after in utero and lactational exposure to either TCDD or PCB126

Rieko Hojo, Masaki Kakeyama, Yoshika Kurokawa, Yasunobu Aoki, Junzo Yonemoto, Chiharu Tohyama

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives: We studied and compared the possible effects of in utero and lactational exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) or 3, 3', 4, 4', 5-pentachlorobiphenyl (PCB126) on learning behavior in offspring. Methods: Pregnant Long-Evans Hooded rats were administered either TCDD (50, 200, or 800 ng/kg) or PCB126 (500, 2,000 or 8,000 ng/kg) on gestational day 15. A procedure of schedule-controlled operant behavior was applied to examine learning behavior in the male and female offspring at 11 weeks of age for 30 days. Three indices, namely, response rates in a fixed ratio (FR) and in a differential reinforcement of low rates (DRL), and reward rate in the DRL component in multiple FR 20 DRL 20 s (mult-FR 20 DRL 20-s) test sessions, were used for the evaluation of learning behavior. Results: Toxic effects on learning behavior in male and female pups following in utero and lactational exposure to TCDD or PCB126 were observed mainly in the FR learning component. However, no linear dose-dependent effects of either of the two compounds were observed for the above three indices. The response rates of animals in the low-dose TCDD and PCB126 groups decreased and those in medium-dose TCDD and PCB126 groups appeared to induce hyperactive behavior. The high dose of PCB126 appeared to have a distinct toxicity from that of TCDD in terms of the acquisition of learning behavior. Conclusions: Toxicities of PCB126 and TCDD in learning behavior might be similar to each other and the current toxic equivalency factor (TEF) of 0.1 for PCB126 can be considered to be appropriate for this endpoint.

Original languageEnglish
Pages (from-to)169-180
Number of pages12
JournalEnvironmental Health and Preventive Medicine
Volume13
Issue number3
DOIs
Publication statusPublished - 2008 May
Externally publishedYes

Fingerprint

Rats
Reinforcement
Learning
Toxicity
3,4,5,3',4'-pentachlorobiphenyl
Poisons
Animals
Long Evans Rats
Polychlorinated Dibenzodioxins
Reward
Appointments and Schedules
Reinforcement (Psychology)

Keywords

  • Learning
  • Operant behavior
  • PCB126
  • Rat
  • TCDD

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Pollution

Cite this

Learning behavior in rat offspring after in utero and lactational exposure to either TCDD or PCB126. / Hojo, Rieko; Kakeyama, Masaki; Kurokawa, Yoshika; Aoki, Yasunobu; Yonemoto, Junzo; Tohyama, Chiharu.

In: Environmental Health and Preventive Medicine, Vol. 13, No. 3, 05.2008, p. 169-180.

Research output: Contribution to journalArticle

Hojo, Rieko ; Kakeyama, Masaki ; Kurokawa, Yoshika ; Aoki, Yasunobu ; Yonemoto, Junzo ; Tohyama, Chiharu. / Learning behavior in rat offspring after in utero and lactational exposure to either TCDD or PCB126. In: Environmental Health and Preventive Medicine. 2008 ; Vol. 13, No. 3. pp. 169-180.
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