TY - JOUR
T1 - Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript
AU - Shigeyoshi, Yasufumi
AU - Taguchi, Kouji
AU - Yamamoto, Shuzo
AU - Takekida, Seiichi
AU - Yan, Lily
AU - Tei, Hajime
AU - Moriya, Takahiro
AU - Shibata, Shigenobu
AU - Loros, Jennifer J.
AU - Dunlap, Jay C.
AU - Okamura, Hitoshi
N1 - Funding Information:
The authors wish to thank Dr. Shin-Ichi Inouye for helpful comments on the manuscript and Dr. Toru Takum for discussion. This work was supported by research grants to H. O. from the Japanese Ministry of Education, Science, Sports and Culture (08557007, 09260219, 09480212) and the Japanese Ministry of Health and Welfare and the Mochida Memorial Foundation, to J. J. L. from the National Science Foundation (MCB-9307299), and the AFOSR (F49620–94–1–0260), to J. C. D. and J. J. L. from the National Institute of Health (MH 44651) and to J. C. D. from the National Institute of Health (GM 34985 and MH01186).
PY - 1997/12/26
Y1 - 1997/12/26
N2 - To understand how light might entrain a mammalian circadian clock, we examined the effects of light on mPer1, a sequence homolog of Drosophila per, that exhibits robust rhythmic expression in the SCN. mPer1 is rapidly induced by short duration exposure to light at levels sufficient to reset the clock, and dose-response curves reveal that mPer1/induction shows both reciprocity and a strong correlation with phase shifting of the overt rhythm. Thus, in both the phasing of dark expression and the response to light mPer1 is most similar to the Neurospora clock gene frq. Within the SCN there appears to be localization of the induction phenomenon, consistent with the localization of both light-sensitive and light-insensitive oscillators in this circadian center.
AB - To understand how light might entrain a mammalian circadian clock, we examined the effects of light on mPer1, a sequence homolog of Drosophila per, that exhibits robust rhythmic expression in the SCN. mPer1 is rapidly induced by short duration exposure to light at levels sufficient to reset the clock, and dose-response curves reveal that mPer1/induction shows both reciprocity and a strong correlation with phase shifting of the overt rhythm. Thus, in both the phasing of dark expression and the response to light mPer1 is most similar to the Neurospora clock gene frq. Within the SCN there appears to be localization of the induction phenomenon, consistent with the localization of both light-sensitive and light-insensitive oscillators in this circadian center.
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U2 - 10.1016/S0092-8674(00)80494-8
DO - 10.1016/S0092-8674(00)80494-8
M3 - Article
C2 - 9428526
AN - SCOPUS:0031459479
SN - 0092-8674
VL - 91
SP - 1043
EP - 1053
JO - Cell
JF - Cell
IS - 7
ER -