Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript

Yasufumi Shigeyoshi, Kouji Taguchi, Shuzo Yamamoto, Seiichi Takekida, Lily Yan, Hajime Tei, Takahiro Moriya, Shigenobu Shibata, Jennifer J. Loros, Jay C. Dunlap, Hitoshi Okamura

    Research output: Contribution to journalArticle

    668 Citations (Scopus)

    Abstract

    To understand how light might entrain a mammalian circadian clock, we examined the effects of light on mPer1, a sequence homolog of Drosophila per, that exhibits robust rhythmic expression in the SCN. mPer1 is rapidly induced by short duration exposure to light at levels sufficient to reset the clock, and dose-response curves reveal that mPer1/induction shows both reciprocity and a strong correlation with phase shifting of the overt rhythm. Thus, in both the phasing of dark expression and the response to light mPer1 is most similar to the Neurospora clock gene frq. Within the SCN there appears to be localization of the induction phenomenon, consistent with the localization of both light-sensitive and light-insensitive oscillators in this circadian center.

    Original languageEnglish
    Pages (from-to)1043-1053
    Number of pages11
    JournalCell
    Volume91
    Issue number7
    DOIs
    Publication statusPublished - 1997 Dec 26

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    Circadian Clocks
    Clocks
    Light
    Neurospora
    Sequence Homology
    Drosophila
    Genes

    ASJC Scopus subject areas

    • Cell Biology
    • Molecular Biology

    Cite this

    Shigeyoshi, Y., Taguchi, K., Yamamoto, S., Takekida, S., Yan, L., Tei, H., ... Okamura, H. (1997). Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript. Cell, 91(7), 1043-1053. https://doi.org/10.1016/S0092-8674(00)80494-8

    Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript. / Shigeyoshi, Yasufumi; Taguchi, Kouji; Yamamoto, Shuzo; Takekida, Seiichi; Yan, Lily; Tei, Hajime; Moriya, Takahiro; Shibata, Shigenobu; Loros, Jennifer J.; Dunlap, Jay C.; Okamura, Hitoshi.

    In: Cell, Vol. 91, No. 7, 26.12.1997, p. 1043-1053.

    Research output: Contribution to journalArticle

    Shigeyoshi, Y, Taguchi, K, Yamamoto, S, Takekida, S, Yan, L, Tei, H, Moriya, T, Shibata, S, Loros, JJ, Dunlap, JC & Okamura, H 1997, 'Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript', Cell, vol. 91, no. 7, pp. 1043-1053. https://doi.org/10.1016/S0092-8674(00)80494-8
    Shigeyoshi, Yasufumi ; Taguchi, Kouji ; Yamamoto, Shuzo ; Takekida, Seiichi ; Yan, Lily ; Tei, Hajime ; Moriya, Takahiro ; Shibata, Shigenobu ; Loros, Jennifer J. ; Dunlap, Jay C. ; Okamura, Hitoshi. / Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript. In: Cell. 1997 ; Vol. 91, No. 7. pp. 1043-1053.
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    AU - Yan, Lily

    AU - Tei, Hajime

    AU - Moriya, Takahiro

    AU - Shibata, Shigenobu

    AU - Loros, Jennifer J.

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