Light-regulated activation of cellular signaling by gold nanoparticles that capture and release amines

Jun Nakanishi, Hidekazu Nakayama, Takahiro Shimizu, Haruhisa Ishida, Yukiko Kikuchi, Kazuo Yamaguchi, Yasuhiro Horiike

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

A photoresponsive nanocarrier for amines based on gold nanoparticles (GNPs) having a photocleavable succinimidyl ester has been developed. It offers a useful platform for the synthesis of caged compounds. Using the GNPs, we have developed caged histamine for the first time and applied it to evoke intracellular signaling by controlled near-UV irradiation. The present work will allow for new possibilities in studies of inter- and intracellular signaling networks.

Original languageEnglish
Pages (from-to)3822-3823
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number11
DOIs
Publication statusPublished - 2009 Mar 25
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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