Light-regulated activation of cellular signaling by gold nanoparticles that capture and release amines

Jun Nakanishi, Hidekazu Nakayama, Takahiro Shimizu, Haruhisa Ishida, Yukiko Kikuchi, Kazuo Yamaguchi, Yasuhiro Horiike

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

A photoresponsive nanocarrier for amines based on gold nanoparticles (GNPs) having a photocleavable succinimidyl ester has been developed. It offers a useful platform for the synthesis of caged compounds. Using the GNPs, we have developed caged histamine for the first time and applied it to evoke intracellular signaling by controlled near-UV irradiation. The present work will allow for new possibilities in studies of inter- and intracellular signaling networks.

Original languageEnglish
Pages (from-to)3822-3823
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number11
DOIs
Publication statusPublished - 2009 Mar 25
Externally publishedYes

Fingerprint

Cell signaling
Gold
Nanoparticles
Amines
Chemical activation
Light
Histamine
Esters
Irradiation

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Light-regulated activation of cellular signaling by gold nanoparticles that capture and release amines. / Nakanishi, Jun; Nakayama, Hidekazu; Shimizu, Takahiro; Ishida, Haruhisa; Kikuchi, Yukiko; Yamaguchi, Kazuo; Horiike, Yasuhiro.

In: Journal of the American Chemical Society, Vol. 131, No. 11, 25.03.2009, p. 3822-3823.

Research output: Contribution to journalArticle

Nakanishi, Jun ; Nakayama, Hidekazu ; Shimizu, Takahiro ; Ishida, Haruhisa ; Kikuchi, Yukiko ; Yamaguchi, Kazuo ; Horiike, Yasuhiro. / Light-regulated activation of cellular signaling by gold nanoparticles that capture and release amines. In: Journal of the American Chemical Society. 2009 ; Vol. 131, No. 11. pp. 3822-3823.
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