Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs.

Makoto Yuasa, Kenichi Oyaizu, Aiko Horiuchi, Akihiko Ogata, Tomomi Hatsugai, Aritomo Yamaguchi, Hiroyoshi Kawakami

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A novel design of anticancer drug delivery system, based on an electrostatic binding of negatively charged liposomes and cationic metalloporphyrins under physiological conditions, is reported. A lack of cytotoxicity of the iron(III) porphyrin-loaded liposomes and an efficient generation of a toxic hydroxyl radical (OH*) from a superoxide anion radical (O2-*) through the iron(III)-catalyzed dismutation and the Fenton-like reaction allow for a targeted necrosis of tumor cells where the concentration of O2-* is locally increased as a result of the reduced activity of superoxide dismutase and catalase in these cells.

Original languageEnglish
Pages (from-to)387-389
Number of pages3
JournalMol Pharm
Volume1
Issue number5
Publication statusPublished - 2004 Sep
Externally publishedYes

Fingerprint

Porphyrins
Liposomes
Superoxides
Iron
Metalloporphyrins
Water
Poisons
Drug Delivery Systems
Static Electricity
Pharmaceutical Preparations
Hydroxyl Radical
Catalase
Superoxide Dismutase
Necrosis
Neoplasms

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

Cite this

Yuasa, M., Oyaizu, K., Horiuchi, A., Ogata, A., Hatsugai, T., Yamaguchi, A., & Kawakami, H. (2004). Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs. Mol Pharm, 1(5), 387-389.

Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs. / Yuasa, Makoto; Oyaizu, Kenichi; Horiuchi, Aiko; Ogata, Akihiko; Hatsugai, Tomomi; Yamaguchi, Aritomo; Kawakami, Hiroyoshi.

In: Mol Pharm, Vol. 1, No. 5, 09.2004, p. 387-389.

Research output: Contribution to journalArticle

Yuasa, M, Oyaizu, K, Horiuchi, A, Ogata, A, Hatsugai, T, Yamaguchi, A & Kawakami, H 2004, 'Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs.', Mol Pharm, vol. 1, no. 5, pp. 387-389.
Yuasa M, Oyaizu K, Horiuchi A, Ogata A, Hatsugai T, Yamaguchi A et al. Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs. Mol Pharm. 2004 Sep;1(5):387-389.
Yuasa, Makoto ; Oyaizu, Kenichi ; Horiuchi, Aiko ; Ogata, Akihiko ; Hatsugai, Tomomi ; Yamaguchi, Aritomo ; Kawakami, Hiroyoshi. / Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs. In: Mol Pharm. 2004 ; Vol. 1, No. 5. pp. 387-389.
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