Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs.

Makoto Yuasa, Kenichi Oyaizu, Aiko Horiuchi, Akihiko Ogata, Tomomi Hatsugai, Aritomo Yamaguchi, Hiroyoshi Kawakami

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30 Citations (Scopus)

Abstract

A novel design of anticancer drug delivery system, based on an electrostatic binding of negatively charged liposomes and cationic metalloporphyrins under physiological conditions, is reported. A lack of cytotoxicity of the iron(III) porphyrin-loaded liposomes and an efficient generation of a toxic hydroxyl radical (OH*) from a superoxide anion radical (O2-*) through the iron(III)-catalyzed dismutation and the Fenton-like reaction allow for a targeted necrosis of tumor cells where the concentration of O2-* is locally increased as a result of the reduced activity of superoxide dismutase and catalase in these cells.

Original languageEnglish
Pages (from-to)387-389
Number of pages3
JournalMolecular pharmaceutics
Volume1
Issue number5
Publication statusPublished - 2004 Jan 1

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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  • Cite this

    Yuasa, M., Oyaizu, K., Horiuchi, A., Ogata, A., Hatsugai, T., Yamaguchi, A., & Kawakami, H. (2004). Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs. Molecular pharmaceutics, 1(5), 387-389.