Liposome-embedded heme - totally synthetic oxygen carrier and its oxygen carrying capacity

Koichi Kobayashi, Masazumi Watanabe, Tsuneo Ishihara, Hiroyuki Nishide, Eisyun Tsuchida

Research output: Contribution to journalArticle

Abstract

Synthetic heme was embedded in bilayers of liposome to produce a totally artificial oxygen-carrying substance. The in vivo oxygen-carrying capacity of this liposome-embedded heme (L/H) was studied in dogs. Dogs weighing 8 to 10 kg were anesthetized, intubated and mechanically ventilated with ambient air. A Swan-Ganz catheter and an arterial line were inserted for blood sampling and pressure monitoring. The hemoglobin (Hb) and L/H concentration in the blood were measured. After injection of L/H, cardiac output, Hb and L/H concentration in the blood were measured and oxygen transport by Hb and L/H, oxygen consumption from Hb and L/H, oxygen volume transported in the total oxygen transport, and oxygen volume consumed from L/H in the total oxygen consumption were calculated. It was found that L/H transported oxygen to the tissue, and that oxygen volume transported by L/H and oxygen volume consumed from L/H were proportional to L/H.

Original languageEnglish
Pages (from-to)412
Number of pages1
JournalBiomaterials, Artificial Cells, and Immobilization Biotechnology
Volume19
Issue number2
Publication statusPublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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