Liposome-embedded heme - totally synthetic oxygen carrier and its oxygen carrying capacity

Koichi Kobayashi, Masazumi Watanabe, Tsuneo Ishihara, Hiroyuki Nishide, Eisyun Tsuchida

Research output: Contribution to journalArticle

Abstract

Synthetic heme was embedded in bilayers of liposome to produce a totally artificial oxygen-carrying substance. The in vivo oxygen-carrying capacity of this liposome-embedded heme (L/H) was studied in dogs. Dogs weighing 8 to 10 kg were anesthetized, intubated and mechanically ventilated with ambient air. A Swan-Ganz catheter and an arterial line were inserted for blood sampling and pressure monitoring. The hemoglobin (Hb) and L/H concentration in the blood were measured. After injection of L/H, cardiac output, Hb and L/H concentration in the blood were measured and oxygen transport by Hb and L/H, oxygen consumption from Hb and L/H, oxygen volume transported in the total oxygen transport, and oxygen volume consumed from L/H in the total oxygen consumption were calculated. It was found that L/H transported oxygen to the tissue, and that oxygen volume transported by L/H and oxygen volume consumed from L/H were proportional to L/H.

Original languageEnglish
Pages (from-to)412
Number of pages1
JournalBiomaterials, Artificial Cells, and Immobilization Biotechnology
Volume19
Issue number2
Publication statusPublished - 1991
Externally publishedYes

Fingerprint

Liposomes
Conservation of Natural Resources
Heme
Oxygen
Hemoglobin
Hemoglobins
Blood
Oxygen Consumption
Dogs
Vascular Access Devices
Catheters
Weighing
Cardiac Output
Air
Tissue
Sampling
Blood Pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Liposome-embedded heme - totally synthetic oxygen carrier and its oxygen carrying capacity. / Kobayashi, Koichi; Watanabe, Masazumi; Ishihara, Tsuneo; Nishide, Hiroyuki; Tsuchida, Eisyun.

In: Biomaterials, Artificial Cells, and Immobilization Biotechnology, Vol. 19, No. 2, 1991, p. 412.

Research output: Contribution to journalArticle

Kobayashi, Koichi ; Watanabe, Masazumi ; Ishihara, Tsuneo ; Nishide, Hiroyuki ; Tsuchida, Eisyun. / Liposome-embedded heme - totally synthetic oxygen carrier and its oxygen carrying capacity. In: Biomaterials, Artificial Cells, and Immobilization Biotechnology. 1991 ; Vol. 19, No. 2. pp. 412.
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