Liposome formation of selectively-polymerized diene-containing phospholipids and their postpolymerization

Shinji Takeoka, Hiroyuki Ohno, Hidetaka Iwai, Eishun Tsuchida

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Small and large unilamellar liposomes composed of 1,2-bis(2,4-octadecadienoyl)-sn-glycero-3-phosphorylcholine (DODPC) are prepared by sonication and extrusion, respectively. They are polymerized with water-insoluble radical initiator, azobis(isobutyronitrile) (AIBN) which can selectively polymerize diene groups in 1-acyl chains of the lipids. Polymerized liposomes are freeze-dried to obtain the polymerized liposome powder. For the reconstruction of polymerized liposomes, it is essentially important to design the linear lipid polymers with suitable molecular weight. Higher molecular weight was effective to get stable liposomes but applicable reconstruction methods were limited to milder ones such as ethanol injection method. Postpolymerization of the selectively polymerized DODPC liposomes was very potential method to improve stability through the crosslinking of polymerized membranes regardless of their initial characteristics.

    Original languageEnglish
    Pages (from-to)717-730
    Number of pages14
    JournalJournal of Polymer Science, Part A: Polymer Chemistry
    Volume28
    Issue number4
    DOIs
    Publication statusPublished - 1990 Mar

    Fingerprint

    Liposomes
    Phospholipids
    Lipids
    Molecular weight
    Unilamellar Liposomes
    Sonication
    Phosphorylcholine
    Crosslinking
    Powders
    Extrusion
    Polymers
    Ethanol
    Membranes
    Water

    ASJC Scopus subject areas

    • Polymers and Plastics
    • Materials Chemistry

    Cite this

    Liposome formation of selectively-polymerized diene-containing phospholipids and their postpolymerization. / Takeoka, Shinji; Ohno, Hiroyuki; Iwai, Hidetaka; Tsuchida, Eishun.

    In: Journal of Polymer Science, Part A: Polymer Chemistry, Vol. 28, No. 4, 03.1990, p. 717-730.

    Research output: Contribution to journalArticle

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