Abstract
Three patients with liver cirrhosis (LC) and a bleeding tendency due to marked thrombocytopenia of less than 20 × 109/1 were admitted to our hospital for further examination. Bone marrow examination revealed megakaryocytic hypoplasia in all three patients. All patients exhibited amegakaryocytic thrombocytopenic purpura, myelodysplastic syndrome, or bone marrow hypoplasia. 111In-labeled platelet kinetic studies revealed decreased platelet production in all patients. Although serum thrombopoietin (sTPO) levels are usually within the normal level in patients with LC, the sTPO levels of our patients were about 10 times higher than the levels of normal subjects (1.22 ± 0.37 fmol/ml): 13.34, 16.79, and 10.46 fmol/ml, respectively. These sTPO data supported our findings of decreased megakaryopoiesis. Our findings suggest that examination of sTPO lev els is useful in determining the etiology of marked thrombocytopenia in LC patients.
| Original language | English |
|---|---|
| Pages (from-to) | 52-55 |
| Number of pages | 4 |
| Journal | International Journal of Hematology |
| Volume | 70 |
| Issue number | 1 |
| Publication status | Published - 1999 |
| Externally published | Yes |
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Keywords
- Liver cirrhosis
- Platelet kinetics
- Thrombocytopenia
- Thrombopoietin
ASJC Scopus subject areas
- Hematology
Cite this
Liver cirrhosis with marked thrombocytopenia and highly elevated serum thrombopoietin levels. / Kitano, Kiyoshi; Shimodaira, Shigetaka; Ito, Toshiro; Ichikawa, Naoaki; Kodaira, Hiroshi; Kohara, Yoichi; Ueno, Mayumi; Tahara, Tomoyuki; Kato, Takashi; Ishida, Fumihiro; Kiyosawa, Kendo.
In: International Journal of Hematology, Vol. 70, No. 1, 1999, p. 52-55.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Liver cirrhosis with marked thrombocytopenia and highly elevated serum thrombopoietin levels
AU - Kitano, Kiyoshi
AU - Shimodaira, Shigetaka
AU - Ito, Toshiro
AU - Ichikawa, Naoaki
AU - Kodaira, Hiroshi
AU - Kohara, Yoichi
AU - Ueno, Mayumi
AU - Tahara, Tomoyuki
AU - Kato, Takashi
AU - Ishida, Fumihiro
AU - Kiyosawa, Kendo
PY - 1999
Y1 - 1999
N2 - Three patients with liver cirrhosis (LC) and a bleeding tendency due to marked thrombocytopenia of less than 20 × 109/1 were admitted to our hospital for further examination. Bone marrow examination revealed megakaryocytic hypoplasia in all three patients. All patients exhibited amegakaryocytic thrombocytopenic purpura, myelodysplastic syndrome, or bone marrow hypoplasia. 111In-labeled platelet kinetic studies revealed decreased platelet production in all patients. Although serum thrombopoietin (sTPO) levels are usually within the normal level in patients with LC, the sTPO levels of our patients were about 10 times higher than the levels of normal subjects (1.22 ± 0.37 fmol/ml): 13.34, 16.79, and 10.46 fmol/ml, respectively. These sTPO data supported our findings of decreased megakaryopoiesis. Our findings suggest that examination of sTPO lev els is useful in determining the etiology of marked thrombocytopenia in LC patients.
AB - Three patients with liver cirrhosis (LC) and a bleeding tendency due to marked thrombocytopenia of less than 20 × 109/1 were admitted to our hospital for further examination. Bone marrow examination revealed megakaryocytic hypoplasia in all three patients. All patients exhibited amegakaryocytic thrombocytopenic purpura, myelodysplastic syndrome, or bone marrow hypoplasia. 111In-labeled platelet kinetic studies revealed decreased platelet production in all patients. Although serum thrombopoietin (sTPO) levels are usually within the normal level in patients with LC, the sTPO levels of our patients were about 10 times higher than the levels of normal subjects (1.22 ± 0.37 fmol/ml): 13.34, 16.79, and 10.46 fmol/ml, respectively. These sTPO data supported our findings of decreased megakaryopoiesis. Our findings suggest that examination of sTPO lev els is useful in determining the etiology of marked thrombocytopenia in LC patients.
KW - Liver cirrhosis
KW - Platelet kinetics
KW - Thrombocytopenia
KW - Thrombopoietin
UR - http://www.scopus.com/inward/record.url?scp=0033163246&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033163246&partnerID=8YFLogxK
M3 - Article
C2 - 10446496
AN - SCOPUS:0033163246
VL - 70
SP - 52
EP - 55
JO - International Journal of Hematology
JF - International Journal of Hematology
SN - 0925-5710
IS - 1
ER -