Living microtransporter by uni-directional gliding of Mycoplasma along microtracks

Yuichi Hiratsuka, Makoto Miyata, Taro Q.P. Uyeda

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

The gliding bacterium Mycoplasma mobile adheres to plastic surfaces and moves around vigorously. However, it has not been possible to control the direction of movements on plain surfaces. Here we report that, on patterned lithographic substrates, M. mobile cells are unable to climb tall walls and move along the bottom edge of the walls. This property to move persistently along walls enabled us to design patterns that control direction of movements, resulting in uni-directional circling or one-way gating between two areas. Furthermore, cells loaded with streptavidin beads following biotinylation of surface proteins moved at normal speeds. These bacteria could be useful as living microtransporters, carrying cargo around within micrometer-scale spaces.

Original languageEnglish
Pages (from-to)318-324
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume331
Issue number1
DOIs
Publication statusPublished - 2005 May 27
Externally publishedYes

Keywords

  • Actuator
  • Bacterial motility
  • Bottom up assembly
  • Kinesin
  • Motor protein
  • Synthetic biology

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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