Loading of curcumin into macrophages using lipid-based nanoparticles

Keitaro Sou, Shunsuke Inenaga, Shinji Takeoka, Eishun Tsuchida

    Research output: Contribution to journalArticle

    143 Citations (Scopus)

    Abstract

    Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Cm) is a natural compound which possesses antioxidant, anti-inflammatory and anti-tumor ability. Here, phospholipid vesicles or lipid-nanospheres embedding Cm (CmVe or CmLn) were formulated to deliver Cm into tissue macrophages through intravenous injection. Cm could be solubilized in hydrophobic regions of these particles to form nanoparticle dispersions, and these formulations showed ability to scavenge reactive oxygen species as antioxidants in dispersions. At 6 h after intravenous injection in rats via the tail vein (2 mg Cm/kg bw), confocal microscopic observations of tissue sections showed that Cm was massively distributed in cells assumed as macrophages into the bone marrow and spleen. Taken together, these results indicate that the lipid-based nanoparticulates provide improved intravenous delivery of Cm to tissues macrophages, specifically bone marrow and splenic macrophages in present formulation, which has therapeutic potential as an antioxidant and anti-inflammatory.

    Original languageEnglish
    Pages (from-to)287-293
    Number of pages7
    JournalInternational Journal of Pharmaceutics
    Volume352
    Issue number1-2
    DOIs
    Publication statusPublished - 2008 Mar 20

    Fingerprint

    Curcumin
    Nanoparticles
    Macrophages
    Lipids
    Antioxidants
    Intravenous Injections
    Anti-Inflammatory Agents
    Bone Marrow
    Nanospheres
    Tail
    Veins
    Reactive Oxygen Species
    Phospholipids
    Spleen
    Neoplasms
    Therapeutics

    Keywords

    • Antioxidant
    • Bone marrow
    • Drug delivery
    • Liposomes
    • Macrophage
    • Nanoparticles

    ASJC Scopus subject areas

    • Pharmaceutical Science

    Cite this

    Loading of curcumin into macrophages using lipid-based nanoparticles. / Sou, Keitaro; Inenaga, Shunsuke; Takeoka, Shinji; Tsuchida, Eishun.

    In: International Journal of Pharmaceutics, Vol. 352, No. 1-2, 20.03.2008, p. 287-293.

    Research output: Contribution to journalArticle

    Sou, Keitaro ; Inenaga, Shunsuke ; Takeoka, Shinji ; Tsuchida, Eishun. / Loading of curcumin into macrophages using lipid-based nanoparticles. In: International Journal of Pharmaceutics. 2008 ; Vol. 352, No. 1-2. pp. 287-293.
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