Loading of curcumin into macrophages using lipid-based nanoparticles

Keitaro Sou, Shunsuke Inenaga, Shinji Takeoka, Eishun Tsuchida

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Cm) is a natural compound which possesses antioxidant, anti-inflammatory and anti-tumor ability. Here, phospholipid vesicles or lipid-nanospheres embedding Cm (CmVe or CmLn) were formulated to deliver Cm into tissue macrophages through intravenous injection. Cm could be solubilized in hydrophobic regions of these particles to form nanoparticle dispersions, and these formulations showed ability to scavenge reactive oxygen species as antioxidants in dispersions. At 6 h after intravenous injection in rats via the tail vein (2 mg Cm/kg bw), confocal microscopic observations of tissue sections showed that Cm was massively distributed in cells assumed as macrophages into the bone marrow and spleen. Taken together, these results indicate that the lipid-based nanoparticulates provide improved intravenous delivery of Cm to tissues macrophages, specifically bone marrow and splenic macrophages in present formulation, which has therapeutic potential as an antioxidant and anti-inflammatory.

Original languageEnglish
Pages (from-to)287-293
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume352
Issue number1-2
DOIs
Publication statusPublished - 2008 Mar 20

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Keywords

  • Antioxidant
  • Bone marrow
  • Drug delivery
  • Liposomes
  • Macrophage
  • Nanoparticles

ASJC Scopus subject areas

  • Pharmaceutical Science

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