The rate of local axial gas transport in oscillatory flow through a model human central airways was measured to evaluate the gas exchange during high-frequency oscillation. A rigid model of human airways consists of asymmetrical bifurcations up to third generation, of which geometries were determined by the study of Horsfield et. al. (1971). A bolus of CO 2 tracer was injected into the trachea, and effective diffusivities as a function of location in the airways were obtained by CO 2 washout profiles. The rate of increase of effective diffusivity depends on the local flow conditions and differs with branches. The effective diffusivity in the left main bronchus becomes 3 times greater than that in the straight tube, whereas no significant effect is observed in the right main bronchus.
|Title of host publication||American Society of Mechanical Engineers, Bioengineering Division (Publication) BED|
|Number of pages||2|
|Publication status||Published - 1996|
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