Localization, characterization and function of pituitary adenylate cyclase-activating polypeptide during brain development

Jun Watanabe, Tomoya Nakamachi, Ryousuke Matsuno, Daisuke Hayashi, Masahisa Nakamura, Sakae Kikuyama, Shigeo Nakajo, Seiji Shioda

    Research output: Contribution to journalArticlepeer-review

    50 Citations (Scopus)

    Abstract

    Neural development is controlled by region-specific factors that regulate cell proliferation, migration and differentiation. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that exerts a wide range of effects on different cell types in the brain as early as the fetal stage. Here we review current knowledge concerning several aspects of PACAP expression in embryonic and neonatal neural tissue: (i) the distribution of PACAP and PACAP receptors mRNA in the developing brain; (ii) the characteristic generation of neurons, astrocytes and oligodendrocytes in brain areas where the PACAP receptor is expressed and (iii) the role of PACAP as a regulator of neural development, inducing differentiation and proliferation in association with other trophic factors or signal transduction molecules.

    Original languageEnglish
    Pages (from-to)1713-1719
    Number of pages7
    JournalPeptides
    Volume28
    Issue number9
    DOIs
    Publication statusPublished - 2007 Sep

    Keywords

    • Neural development
    • Neurogenesis
    • PAC1 receptor
    • Pituitary adenylate cyclase-activating Polypeptide (PACAP)

    ASJC Scopus subject areas

    • Biochemistry
    • Endocrinology
    • Physiology
    • Cellular and Molecular Neuroscience

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