Localization, characterization and function of pituitary adenylate cyclase-activating polypeptide during brain development

Jun Watanabe; Tomoya Nakamachi; Ryousuke Matsuno; Daisuke Hayashi; Masahisa Nakamura; Sakae Kikuyama; Shigeo Nakajo; Seiji Shioda

doi:10.1016/j.peptides.2007.06.029

Localization, characterization and function of pituitary adenylate cyclase-activating polypeptide during brain development

Jun Watanabe, Tomoya Nakamachi, Ryousuke Matsuno, Daisuke Hayashi, Masahisa Nakamura, Sakae Kikuyama, Shigeo Nakajo, Seiji Shioda^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Neural development is controlled by region-specific factors that regulate cell proliferation, migration and differentiation. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that exerts a wide range of effects on different cell types in the brain as early as the fetal stage. Here we review current knowledge concerning several aspects of PACAP expression in embryonic and neonatal neural tissue: (i) the distribution of PACAP and PACAP receptors mRNA in the developing brain; (ii) the characteristic generation of neurons, astrocytes and oligodendrocytes in brain areas where the PACAP receptor is expressed and (iii) the role of PACAP as a regulator of neural development, inducing differentiation and proliferation in association with other trophic factors or signal transduction molecules.

Original language	English
Pages (from-to)	1713-1719
Number of pages	7
Journal	Peptides
Volume	28
Issue number	9
DOIs	https://doi.org/10.1016/j.peptides.2007.06.029
Publication status	Published - 2007 Sept

Keywords

Neural development
Neurogenesis
PAC1 receptor
Pituitary adenylate cyclase-activating Polypeptide (PACAP)

ASJC Scopus subject areas

Biochemistry
Endocrinology
Physiology
Cellular and Molecular Neuroscience

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10.1016/j.peptides.2007.06.029

Cite this

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title = "Localization, characterization and function of pituitary adenylate cyclase-activating polypeptide during brain development",

abstract = "Neural development is controlled by region-specific factors that regulate cell proliferation, migration and differentiation. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that exerts a wide range of effects on different cell types in the brain as early as the fetal stage. Here we review current knowledge concerning several aspects of PACAP expression in embryonic and neonatal neural tissue: (i) the distribution of PACAP and PACAP receptors mRNA in the developing brain; (ii) the characteristic generation of neurons, astrocytes and oligodendrocytes in brain areas where the PACAP receptor is expressed and (iii) the role of PACAP as a regulator of neural development, inducing differentiation and proliferation in association with other trophic factors or signal transduction molecules.",

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author = "Jun Watanabe and Tomoya Nakamachi and Ryousuke Matsuno and Daisuke Hayashi and Masahisa Nakamura and Sakae Kikuyama and Shigeo Nakajo and Seiji Shioda",

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T1 - Localization, characterization and function of pituitary adenylate cyclase-activating polypeptide during brain development

AU - Watanabe, Jun

AU - Nakamachi, Tomoya

AU - Matsuno, Ryousuke

AU - Hayashi, Daisuke

AU - Nakamura, Masahisa

AU - Kikuyama, Sakae

AU - Nakajo, Shigeo

AU - Shioda, Seiji

PY - 2007/9

Y1 - 2007/9

N2 - Neural development is controlled by region-specific factors that regulate cell proliferation, migration and differentiation. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that exerts a wide range of effects on different cell types in the brain as early as the fetal stage. Here we review current knowledge concerning several aspects of PACAP expression in embryonic and neonatal neural tissue: (i) the distribution of PACAP and PACAP receptors mRNA in the developing brain; (ii) the characteristic generation of neurons, astrocytes and oligodendrocytes in brain areas where the PACAP receptor is expressed and (iii) the role of PACAP as a regulator of neural development, inducing differentiation and proliferation in association with other trophic factors or signal transduction molecules.

AB - Neural development is controlled by region-specific factors that regulate cell proliferation, migration and differentiation. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that exerts a wide range of effects on different cell types in the brain as early as the fetal stage. Here we review current knowledge concerning several aspects of PACAP expression in embryonic and neonatal neural tissue: (i) the distribution of PACAP and PACAP receptors mRNA in the developing brain; (ii) the characteristic generation of neurons, astrocytes and oligodendrocytes in brain areas where the PACAP receptor is expressed and (iii) the role of PACAP as a regulator of neural development, inducing differentiation and proliferation in association with other trophic factors or signal transduction molecules.

KW - Neural development

KW - Neurogenesis

KW - PAC1 receptor

KW - Pituitary adenylate cyclase-activating Polypeptide (PACAP)

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Localization, characterization and function of pituitary adenylate cyclase-activating polypeptide during brain development

Abstract

Keywords

ASJC Scopus subject areas

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