Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line

S. I. Fukushige, K. I. Matsubara, M. Yoshida, M. Sasaki, T. Suzuki, K. Semba, K. Toyoshima, T. Yamamoto

Research output: Contribution to journalArticle

259 Citations (Scopus)

Abstract

The c-erbB-2 gene is a v-erbB-related proto-oncogene which is distinct from the gene encoding the epidermal growth factor receptor. By using two independent methods, hybridization of both sorted chromosomes and metaphase spreads with cloned c-erbB-2 DNA, we mapped the c-erbB-2 locus on human chromosome 17 at q21, a specific breakpoint observed in a translocation associated with acute promyelocytic leukemia. Furthermore, we observed amplification and elevated expression of the c-erbB-2 gene in the MKN-7 gastric cancer cell line. These data suggest possible involvement of the c-erbB-2 gene in human cancer.

Original languageEnglish
Pages (from-to)955-958
Number of pages4
JournalMolecular and Cellular Biology
Volume6
Issue number3
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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