Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line

S. I. Fukushige, K. I. Matsubara, M. Yoshida, M. Sasaki, T. Suzuki, Kentaro Senba, K. Toyoshima, T. Yamamoto

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Abstract

The c-erbB-2 gene is a v-erbB-related proto-oncogene which is distinct from the gene encoding the epidermal growth factor receptor. By using two independent methods, hybridization of both sorted chromosomes and metaphase spreads with cloned c-erbB-2 DNA, we mapped the c-erbB-2 locus on human chromosome 17 at q21, a specific breakpoint observed in a translocation associated with acute promyelocytic leukemia. Furthermore, we observed amplification and elevated expression of the c-erbB-2 gene in the MKN-7 gastric cancer cell line. These data suggest possible involvement of the c-erbB-2 gene in human cancer.

Original languageEnglish
Pages (from-to)955-958
Number of pages4
JournalMolecular and Cellular Biology
Volume6
Issue number3
Publication statusPublished - 1986
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Fukushige, S. I., Matsubara, K. I., Yoshida, M., Sasaki, M., Suzuki, T., Senba, K., Toyoshima, K., & Yamamoto, T. (1986). Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line. Molecular and Cellular Biology, 6(3), 955-958.