Logic operation in DNA nano device: Electrical input/output through biological nanopore

Kosuke Inoue, Ryuji Kawano, Hiroki Yasuga, Masahiro Takinoue, Toshihisa Osaki, Koki Kamiya, Norihisa Miki, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

This paper describes DNA logic gates with using biological nanopores integrated in the lipid-coated droplet networks. As the biological nanopore, alpha-hemolysin (αHL) is reconstituted in droplet interface bilayers (DIBs) which can be prepared with splitting and re-attaching the lipid monolayers by mechanical motion in split-and-contact device; SCD. Since DIBs can be instantly formed by SCD, we can use the rupture of DIBs to transfer DNA between droplets as inputs for logic operation. In this study, we demonstrated OR and NOT gates using this input system with SCD. The rapid and repeated calculation can be performed in this system.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages1881-1883
Number of pages3
ISBN (Print)9781632666246
Publication statusPublished - 2013 Jan 1
Externally publishedYes
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: 2013 Oct 272013 Oct 31

Publication series

Name17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume3

Conference

Conference17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period13/10/2713/10/31

Keywords

  • Biological nanopore
  • Droplet networks
  • Lipid bilayer
  • Logic operation

ASJC Scopus subject areas

  • Bioengineering

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