Long-term prognostic assessment of 185 newly diagnosed gliomas - Grade III glioma showed prognosis comparable to that of grade II glioma

Chie Shinohara, Yoshihiro Muragaki, Takashi Maruyama, Satoru Shimizu, Masahiko Tanaka, Yuichi Kubota, Mitsuteru Oikawa, Ryoichi Nakamura, Hiroshi Iseki, Osami Kubo, Kintomo Takakura, Tomokatsu Hori

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: We evaluated the prognoses of newly diagnosed gliomas through WHO Grades II, III and IV to assess the overall tendency of treatment results for glioma in our institute. Furthermore, statistical analysis was performed to determine factors influencing the prognosis. Methods: A total of 185 newly diagnosed glioma patients were operated on from 2000 to 2006. The primary endpoint was the overall survival from the date of surgery. The factors assessed as to whether they influenced the prognosis were the WHO grades of sex, age, location of the lesion, pre-operative Karnofsky Performance Status (KPS), extent of resection and whether or not radiation therapy was performed. Results: The WHO grades influenced the survival significantly (P < 0.0001). The Grades II and III showed no statistically significant difference in survival (P = 0.174), whereas Grades III and IV showed a significant difference (P < 0.0001). The factor influencing survival as well as the grades was the KPS (P < 0.0001). The comparison of survival over WHO grades in the same KPS group was performed for 2 KPS groups (KPS = 100, KPS 80-90), and these also showed significant differences (P = 0.0009 and 0.0143, respectively). Conclusions: Despite the different distributions of the KPS, the Grade III glioma patients showed survival comparable to that of the Grade II. On the other hand, the Grade IV glioma patients showed significantly poorer survival compared with Grade II or III.

Original languageEnglish
Pages (from-to)730-733
Number of pages4
JournalJapanese Journal of Clinical Oncology
Volume38
Issue number11
DOIs
Publication statusPublished - 2008
Externally publishedYes

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Karnofsky Performance Status
Glioma
Survival
Radiotherapy

Keywords

  • Glioma
  • Long-term prognosis
  • WHO grade

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Radiology Nuclear Medicine and imaging

Cite this

Long-term prognostic assessment of 185 newly diagnosed gliomas - Grade III glioma showed prognosis comparable to that of grade II glioma. / Shinohara, Chie; Muragaki, Yoshihiro; Maruyama, Takashi; Shimizu, Satoru; Tanaka, Masahiko; Kubota, Yuichi; Oikawa, Mitsuteru; Nakamura, Ryoichi; Iseki, Hiroshi; Kubo, Osami; Takakura, Kintomo; Hori, Tomokatsu.

In: Japanese Journal of Clinical Oncology, Vol. 38, No. 11, 2008, p. 730-733.

Research output: Contribution to journalArticle

Shinohara, C, Muragaki, Y, Maruyama, T, Shimizu, S, Tanaka, M, Kubota, Y, Oikawa, M, Nakamura, R, Iseki, H, Kubo, O, Takakura, K & Hori, T 2008, 'Long-term prognostic assessment of 185 newly diagnosed gliomas - Grade III glioma showed prognosis comparable to that of grade II glioma', Japanese Journal of Clinical Oncology, vol. 38, no. 11, pp. 730-733. https://doi.org/10.1093/jjco/hyn099
Shinohara, Chie ; Muragaki, Yoshihiro ; Maruyama, Takashi ; Shimizu, Satoru ; Tanaka, Masahiko ; Kubota, Yuichi ; Oikawa, Mitsuteru ; Nakamura, Ryoichi ; Iseki, Hiroshi ; Kubo, Osami ; Takakura, Kintomo ; Hori, Tomokatsu. / Long-term prognostic assessment of 185 newly diagnosed gliomas - Grade III glioma showed prognosis comparable to that of grade II glioma. In: Japanese Journal of Clinical Oncology. 2008 ; Vol. 38, No. 11. pp. 730-733.
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AU - Muragaki, Yoshihiro

AU - Maruyama, Takashi

AU - Shimizu, Satoru

AU - Tanaka, Masahiko

AU - Kubota, Yuichi

AU - Oikawa, Mitsuteru

AU - Nakamura, Ryoichi

AU - Iseki, Hiroshi

AU - Kubo, Osami

AU - Takakura, Kintomo

AU - Hori, Tomokatsu

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N2 - Objective: We evaluated the prognoses of newly diagnosed gliomas through WHO Grades II, III and IV to assess the overall tendency of treatment results for glioma in our institute. Furthermore, statistical analysis was performed to determine factors influencing the prognosis. Methods: A total of 185 newly diagnosed glioma patients were operated on from 2000 to 2006. The primary endpoint was the overall survival from the date of surgery. The factors assessed as to whether they influenced the prognosis were the WHO grades of sex, age, location of the lesion, pre-operative Karnofsky Performance Status (KPS), extent of resection and whether or not radiation therapy was performed. Results: The WHO grades influenced the survival significantly (P < 0.0001). The Grades II and III showed no statistically significant difference in survival (P = 0.174), whereas Grades III and IV showed a significant difference (P < 0.0001). The factor influencing survival as well as the grades was the KPS (P < 0.0001). The comparison of survival over WHO grades in the same KPS group was performed for 2 KPS groups (KPS = 100, KPS 80-90), and these also showed significant differences (P = 0.0009 and 0.0143, respectively). Conclusions: Despite the different distributions of the KPS, the Grade III glioma patients showed survival comparable to that of the Grade II. On the other hand, the Grade IV glioma patients showed significantly poorer survival compared with Grade II or III.

AB - Objective: We evaluated the prognoses of newly diagnosed gliomas through WHO Grades II, III and IV to assess the overall tendency of treatment results for glioma in our institute. Furthermore, statistical analysis was performed to determine factors influencing the prognosis. Methods: A total of 185 newly diagnosed glioma patients were operated on from 2000 to 2006. The primary endpoint was the overall survival from the date of surgery. The factors assessed as to whether they influenced the prognosis were the WHO grades of sex, age, location of the lesion, pre-operative Karnofsky Performance Status (KPS), extent of resection and whether or not radiation therapy was performed. Results: The WHO grades influenced the survival significantly (P < 0.0001). The Grades II and III showed no statistically significant difference in survival (P = 0.174), whereas Grades III and IV showed a significant difference (P < 0.0001). The factor influencing survival as well as the grades was the KPS (P < 0.0001). The comparison of survival over WHO grades in the same KPS group was performed for 2 KPS groups (KPS = 100, KPS 80-90), and these also showed significant differences (P = 0.0009 and 0.0143, respectively). Conclusions: Despite the different distributions of the KPS, the Grade III glioma patients showed survival comparable to that of the Grade II. On the other hand, the Grade IV glioma patients showed significantly poorer survival compared with Grade II or III.

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