Long-term trends in cardiorespiratory fitness and the incidence of type 2 diabetes

Susumu Sawada, I. Min Lee, Hisashi Naito, Jun Noguchi, Koji Tsukamoto, Takashi Muto, Yasuki Higaki, Hiroaki Tanaka, Steven N. Blair

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

OBJECTIVE - Whereas single assessments of cardiorespiratory fitness have been shown to predict lower incidence of type 2 diabetes, there are no data on long-term trends in fitness and risk. We investigated the relationship between long-term trends in fitness and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS - A cohort of 4,187 Japanese men free of diabetes completed annual health checkups and fitness tests for estimated maximal oxygen uptake at least four times over 7 years (1979-1985). We modeled the trend in fitness over 7 years for each man using simple linear regression. Men were then divided into quartiles based on the regression coefficient (slope) from the model. During the follow-up period (1985-1999), 274 men developed diabetes. Hazard ratios (HRs) and 95% CIs for the incidence of diabetes were obtained using the Cox proportional hazards model. RESULTS - Men in the lowest quartile of the distribution decreased in fitness over the 7 years (median slope -1.25 ml/kg/min), whereas men in the highest quartile increased in fitness (median slope 1.33 ml/kg/min). With adjustment for age, initial fitness level, BMI, systolic blood pressure, cigarette smoking, alcohol intake, and a family history of diabetes and use of the lowest quartile, the HRs (95% CI) for the second through fourth quartiles were 0.64 (0.46-0.89), 0.40 (0.27-0.58), and 0.33 (0.21-0.50), respectively (Ptrend < 0.001). CONCLUSIONS - These results indicate that the long-term trend in fitness is a strong predictor of the incidence of type 2 diabetes in Japanese men.

Original languageEnglish
Pages (from-to)1353-1357
Number of pages5
JournalDiabetes Care
Volume33
Issue number6
DOIs
Publication statusPublished - 2010 Jun 1
Externally publishedYes

Fingerprint

Type 2 Diabetes Mellitus
Incidence
Blood Pressure
Cardiorespiratory Fitness
Proportional Hazards Models
Linear Models
Research Design
Smoking
Alcohols
Oxygen
Health

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Sawada, S., Lee, I. M., Naito, H., Noguchi, J., Tsukamoto, K., Muto, T., ... Blair, S. N. (2010). Long-term trends in cardiorespiratory fitness and the incidence of type 2 diabetes. Diabetes Care, 33(6), 1353-1357. https://doi.org/10.2337/dc09-1654

Long-term trends in cardiorespiratory fitness and the incidence of type 2 diabetes. / Sawada, Susumu; Lee, I. Min; Naito, Hisashi; Noguchi, Jun; Tsukamoto, Koji; Muto, Takashi; Higaki, Yasuki; Tanaka, Hiroaki; Blair, Steven N.

In: Diabetes Care, Vol. 33, No. 6, 01.06.2010, p. 1353-1357.

Research output: Contribution to journalArticle

Sawada, S, Lee, IM, Naito, H, Noguchi, J, Tsukamoto, K, Muto, T, Higaki, Y, Tanaka, H & Blair, SN 2010, 'Long-term trends in cardiorespiratory fitness and the incidence of type 2 diabetes', Diabetes Care, vol. 33, no. 6, pp. 1353-1357. https://doi.org/10.2337/dc09-1654
Sawada, Susumu ; Lee, I. Min ; Naito, Hisashi ; Noguchi, Jun ; Tsukamoto, Koji ; Muto, Takashi ; Higaki, Yasuki ; Tanaka, Hiroaki ; Blair, Steven N. / Long-term trends in cardiorespiratory fitness and the incidence of type 2 diabetes. In: Diabetes Care. 2010 ; Vol. 33, No. 6. pp. 1353-1357.
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