Lordosis in male rats: The facilitatory effect of mesencephalic dorsal raphe nucleus lesion

Masaki Kakeyama; Korehito Yamanouchi

doi:10.1016/0031-9384(92)90221-M

Lordosis in male rats: The facilitatory effect of mesencephalic dorsal raphe nucleus lesion

Masaki Kakeyama, Korehito Yamanouchi^*

^*Corresponding author for this work

School of Human Sciences

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The dorsal raphe nucleus was destroyed (DRL) by a radiofrequency lesion generator in castrated male rats, and lordosis behavior was observed. Five weeks after the surgery, all animals were implanted with two Silastic tubes containing estradiol (E₂). Behavioral tests were started 2 days after implantation of E₂ and carried out every other day for 16 days. Castrated control and sham-operated control males showed low incidence of lordosis and low lordosis quotient (LQ) throughout the tests, whereas all the DRL males displayed lordosis and the mean LQ of the group was significantly higher than that of control groups, but lower than that of an ovariectomized female group. These results suggest that the dorsal raphe nucleus plays an important role in inhibiting lordosis in male rat brain.

Original language	English
Pages (from-to)	181-184
Number of pages	4
Journal	Physiology and Behavior
Volume	51
Issue number	1
DOIs	https://doi.org/10.1016/0031-9384(92)90221-M
Publication status	Published - 1992 Jan

Keywords

Dorsal raphe nucleus
Inhibitory system
Lesions
Lordosis behavior
Male rat
Midbrain

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

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10.1016/0031-9384(92)90221-M

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abstract = "The dorsal raphe nucleus was destroyed (DRL) by a radiofrequency lesion generator in castrated male rats, and lordosis behavior was observed. Five weeks after the surgery, all animals were implanted with two Silastic tubes containing estradiol (E2). Behavioral tests were started 2 days after implantation of E2 and carried out every other day for 16 days. Castrated control and sham-operated control males showed low incidence of lordosis and low lordosis quotient (LQ) throughout the tests, whereas all the DRL males displayed lordosis and the mean LQ of the group was significantly higher than that of control groups, but lower than that of an ovariectomized female group. These results suggest that the dorsal raphe nucleus plays an important role in inhibiting lordosis in male rat brain.",

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AU - Kakeyama, Masaki

AU - Yamanouchi, Korehito

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N2 - The dorsal raphe nucleus was destroyed (DRL) by a radiofrequency lesion generator in castrated male rats, and lordosis behavior was observed. Five weeks after the surgery, all animals were implanted with two Silastic tubes containing estradiol (E2). Behavioral tests were started 2 days after implantation of E2 and carried out every other day for 16 days. Castrated control and sham-operated control males showed low incidence of lordosis and low lordosis quotient (LQ) throughout the tests, whereas all the DRL males displayed lordosis and the mean LQ of the group was significantly higher than that of control groups, but lower than that of an ovariectomized female group. These results suggest that the dorsal raphe nucleus plays an important role in inhibiting lordosis in male rat brain.

AB - The dorsal raphe nucleus was destroyed (DRL) by a radiofrequency lesion generator in castrated male rats, and lordosis behavior was observed. Five weeks after the surgery, all animals were implanted with two Silastic tubes containing estradiol (E2). Behavioral tests were started 2 days after implantation of E2 and carried out every other day for 16 days. Castrated control and sham-operated control males showed low incidence of lordosis and low lordosis quotient (LQ) throughout the tests, whereas all the DRL males displayed lordosis and the mean LQ of the group was significantly higher than that of control groups, but lower than that of an ovariectomized female group. These results suggest that the dorsal raphe nucleus plays an important role in inhibiting lordosis in male rat brain.

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KW - Midbrain

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Lordosis in male rats: The facilitatory effect of mesencephalic dorsal raphe nucleus lesion

Abstract

Keywords

ASJC Scopus subject areas

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