Lordosis-inhibiting effect of progesterone in female rats with lesions in septum, preoptic area, or dorsal raphe nucleus

Motoyasu Satou, Korehito Yamanouchi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Radiofrequency lesions in the septum (SL), the preoptic area (POAL), or the dorsal raphe nucleus (DRL) were made in ovariectomized rats. In a control group of 16 females, ovariectomy, but no brain surgery, was performed. All animals except half of the control rats received injections of 5 mg progesterone (P) 1 h prior to the injection of 5 μg/kg b.w. of estradiol benzoate (EB). Instead of 5 mg P, oil was administered to half of the controls. Forty-four hours after EB, all females received 0.5 mg P. A sexual behavior test was performed 4 h after the last injection of P. The result was that oil-treated control rats showed high lordosis quotient (LQ) and soliciting behavior. in contrast, low scores of LQ and no soliciting behavior were observed in all of the 5 mg P-treated rats, even if the SL, POAL, or DRL was made. These results suggest that the septum, the preoptic area, and the dorsal raphe nucleus are not essential for the female sexual behavior-inhibiting mechanisms of progesterone.

Original languageEnglish
Pages (from-to)1027-1031
Number of pages5
JournalPhysiology and Behavior
Volume60
Issue number3
DOIs
Publication statusPublished - 1996 Sep

Fingerprint

Lordosis
Preoptic Area
Progesterone
Sexual Behavior
Injections
Oils
Ovariectomy
Control Groups
Dorsal Raphe Nucleus
Brain
estradiol 3-benzoate

Keywords

  • Dorsal raphe nucleus
  • Female rat
  • Inhibition
  • Lordosis
  • Preoptic area
  • Progesterone
  • Septum
  • Soliciting behavior

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Physiology (medical)

Cite this

Lordosis-inhibiting effect of progesterone in female rats with lesions in septum, preoptic area, or dorsal raphe nucleus. / Satou, Motoyasu; Yamanouchi, Korehito.

In: Physiology and Behavior, Vol. 60, No. 3, 09.1996, p. 1027-1031.

Research output: Contribution to journalArticle

@article{8a971a4932624395acc6dc50be0f5db4,
title = "Lordosis-inhibiting effect of progesterone in female rats with lesions in septum, preoptic area, or dorsal raphe nucleus",
abstract = "Radiofrequency lesions in the septum (SL), the preoptic area (POAL), or the dorsal raphe nucleus (DRL) were made in ovariectomized rats. In a control group of 16 females, ovariectomy, but no brain surgery, was performed. All animals except half of the control rats received injections of 5 mg progesterone (P) 1 h prior to the injection of 5 μg/kg b.w. of estradiol benzoate (EB). Instead of 5 mg P, oil was administered to half of the controls. Forty-four hours after EB, all females received 0.5 mg P. A sexual behavior test was performed 4 h after the last injection of P. The result was that oil-treated control rats showed high lordosis quotient (LQ) and soliciting behavior. in contrast, low scores of LQ and no soliciting behavior were observed in all of the 5 mg P-treated rats, even if the SL, POAL, or DRL was made. These results suggest that the septum, the preoptic area, and the dorsal raphe nucleus are not essential for the female sexual behavior-inhibiting mechanisms of progesterone.",
keywords = "Dorsal raphe nucleus, Female rat, Inhibition, Lordosis, Preoptic area, Progesterone, Septum, Soliciting behavior",
author = "Motoyasu Satou and Korehito Yamanouchi",
year = "1996",
month = "9",
doi = "10.1016/S0031-9384(96)00139-4",
language = "English",
volume = "60",
pages = "1027--1031",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Lordosis-inhibiting effect of progesterone in female rats with lesions in septum, preoptic area, or dorsal raphe nucleus

AU - Satou, Motoyasu

AU - Yamanouchi, Korehito

PY - 1996/9

Y1 - 1996/9

N2 - Radiofrequency lesions in the septum (SL), the preoptic area (POAL), or the dorsal raphe nucleus (DRL) were made in ovariectomized rats. In a control group of 16 females, ovariectomy, but no brain surgery, was performed. All animals except half of the control rats received injections of 5 mg progesterone (P) 1 h prior to the injection of 5 μg/kg b.w. of estradiol benzoate (EB). Instead of 5 mg P, oil was administered to half of the controls. Forty-four hours after EB, all females received 0.5 mg P. A sexual behavior test was performed 4 h after the last injection of P. The result was that oil-treated control rats showed high lordosis quotient (LQ) and soliciting behavior. in contrast, low scores of LQ and no soliciting behavior were observed in all of the 5 mg P-treated rats, even if the SL, POAL, or DRL was made. These results suggest that the septum, the preoptic area, and the dorsal raphe nucleus are not essential for the female sexual behavior-inhibiting mechanisms of progesterone.

AB - Radiofrequency lesions in the septum (SL), the preoptic area (POAL), or the dorsal raphe nucleus (DRL) were made in ovariectomized rats. In a control group of 16 females, ovariectomy, but no brain surgery, was performed. All animals except half of the control rats received injections of 5 mg progesterone (P) 1 h prior to the injection of 5 μg/kg b.w. of estradiol benzoate (EB). Instead of 5 mg P, oil was administered to half of the controls. Forty-four hours after EB, all females received 0.5 mg P. A sexual behavior test was performed 4 h after the last injection of P. The result was that oil-treated control rats showed high lordosis quotient (LQ) and soliciting behavior. in contrast, low scores of LQ and no soliciting behavior were observed in all of the 5 mg P-treated rats, even if the SL, POAL, or DRL was made. These results suggest that the septum, the preoptic area, and the dorsal raphe nucleus are not essential for the female sexual behavior-inhibiting mechanisms of progesterone.

KW - Dorsal raphe nucleus

KW - Female rat

KW - Inhibition

KW - Lordosis

KW - Preoptic area

KW - Progesterone

KW - Septum

KW - Soliciting behavior

UR - http://www.scopus.com/inward/record.url?scp=0030249620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030249620&partnerID=8YFLogxK

U2 - 10.1016/S0031-9384(96)00139-4

DO - 10.1016/S0031-9384(96)00139-4

M3 - Article

C2 - 8873287

AN - SCOPUS:0030249620

VL - 60

SP - 1027

EP - 1031

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 3

ER -