Low cardiac output leads hepatic fibrosis in right heart failure model rats

Yoshitaka Fujimoto, Takashi Urashima, Daisuke Shimura, Reiji Ito, Sadataka Kawachi, Ichige Kajimura, Toru Akaike, Yoichiro Kusakari, Masako Fujiwara, Kiyoshi Ogawa, Nobuhito Goda, Hiroyuki Ida, Susumu Minamisawa

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Background: Hepatic fibrosis progresses with right heart failure, and becomes cardiac cirrhosis in a severe case. Although its causal factor still remains unclear. Here we evaluated the progression of hepatic fibrosis using a pulmonary artery banding (PAB)-induced right heart failure model and investigated whether cardiac output (CO) is responsible for the progression of hepatic fibrosis. Methods and Results: Five-week-old Sprague-Dawley rats divided into the PAB and sham-operated control groups. After 4 weeks from operation, we measured CO by echocardiography, and hepatic fibrosis ratio by pathological examination using a color analyzer. In the PAB group, CO was significantly lower by 48% than that in the control group (78.2±27.6 and 150.1±31.2 ml/min, P

    Original languageEnglish
    Article numbere0148666
    JournalPLoS One
    Volume11
    Issue number2
    DOIs
    Publication statusPublished - 2016 Feb 1

    Fingerprint

    Low Cardiac Output
    liver cirrhosis
    heart failure
    cardiac output
    Rats
    pulmonary artery
    Fibrosis
    Heart Failure
    animal models
    Echocardiography
    Cardiac Output
    Liver
    Pulmonary Artery
    Color
    echocardiography
    Control Groups
    Sprague Dawley Rats
    color
    rats

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Medicine(all)

    Cite this

    Fujimoto, Y., Urashima, T., Shimura, D., Ito, R., Kawachi, S., Kajimura, I., ... Minamisawa, S. (2016). Low cardiac output leads hepatic fibrosis in right heart failure model rats. PLoS One, 11(2), [e0148666]. https://doi.org/10.1371/journal.pone.0148666

    Low cardiac output leads hepatic fibrosis in right heart failure model rats. / Fujimoto, Yoshitaka; Urashima, Takashi; Shimura, Daisuke; Ito, Reiji; Kawachi, Sadataka; Kajimura, Ichige; Akaike, Toru; Kusakari, Yoichiro; Fujiwara, Masako; Ogawa, Kiyoshi; Goda, Nobuhito; Ida, Hiroyuki; Minamisawa, Susumu.

    In: PLoS One, Vol. 11, No. 2, e0148666, 01.02.2016.

    Research output: Contribution to journalArticle

    Fujimoto, Y, Urashima, T, Shimura, D, Ito, R, Kawachi, S, Kajimura, I, Akaike, T, Kusakari, Y, Fujiwara, M, Ogawa, K, Goda, N, Ida, H & Minamisawa, S 2016, 'Low cardiac output leads hepatic fibrosis in right heart failure model rats', PLoS One, vol. 11, no. 2, e0148666. https://doi.org/10.1371/journal.pone.0148666
    Fujimoto Y, Urashima T, Shimura D, Ito R, Kawachi S, Kajimura I et al. Low cardiac output leads hepatic fibrosis in right heart failure model rats. PLoS One. 2016 Feb 1;11(2). e0148666. https://doi.org/10.1371/journal.pone.0148666
    Fujimoto, Yoshitaka ; Urashima, Takashi ; Shimura, Daisuke ; Ito, Reiji ; Kawachi, Sadataka ; Kajimura, Ichige ; Akaike, Toru ; Kusakari, Yoichiro ; Fujiwara, Masako ; Ogawa, Kiyoshi ; Goda, Nobuhito ; Ida, Hiroyuki ; Minamisawa, Susumu. / Low cardiac output leads hepatic fibrosis in right heart failure model rats. In: PLoS One. 2016 ; Vol. 11, No. 2.
    @article{0c4f87cab263401d93401df50e4fe05d,
    title = "Low cardiac output leads hepatic fibrosis in right heart failure model rats",
    abstract = "Background: Hepatic fibrosis progresses with right heart failure, and becomes cardiac cirrhosis in a severe case. Although its causal factor still remains unclear. Here we evaluated the progression of hepatic fibrosis using a pulmonary artery banding (PAB)-induced right heart failure model and investigated whether cardiac output (CO) is responsible for the progression of hepatic fibrosis. Methods and Results: Five-week-old Sprague-Dawley rats divided into the PAB and sham-operated control groups. After 4 weeks from operation, we measured CO by echocardiography, and hepatic fibrosis ratio by pathological examination using a color analyzer. In the PAB group, CO was significantly lower by 48{\%} than that in the control group (78.2±27.6 and 150.1±31.2 ml/min, P",
    author = "Yoshitaka Fujimoto and Takashi Urashima and Daisuke Shimura and Reiji Ito and Sadataka Kawachi and Ichige Kajimura and Toru Akaike and Yoichiro Kusakari and Masako Fujiwara and Kiyoshi Ogawa and Nobuhito Goda and Hiroyuki Ida and Susumu Minamisawa",
    year = "2016",
    month = "2",
    day = "1",
    doi = "10.1371/journal.pone.0148666",
    language = "English",
    volume = "11",
    journal = "PLoS One",
    issn = "1932-6203",
    publisher = "Public Library of Science",
    number = "2",

    }

    TY - JOUR

    T1 - Low cardiac output leads hepatic fibrosis in right heart failure model rats

    AU - Fujimoto, Yoshitaka

    AU - Urashima, Takashi

    AU - Shimura, Daisuke

    AU - Ito, Reiji

    AU - Kawachi, Sadataka

    AU - Kajimura, Ichige

    AU - Akaike, Toru

    AU - Kusakari, Yoichiro

    AU - Fujiwara, Masako

    AU - Ogawa, Kiyoshi

    AU - Goda, Nobuhito

    AU - Ida, Hiroyuki

    AU - Minamisawa, Susumu

    PY - 2016/2/1

    Y1 - 2016/2/1

    N2 - Background: Hepatic fibrosis progresses with right heart failure, and becomes cardiac cirrhosis in a severe case. Although its causal factor still remains unclear. Here we evaluated the progression of hepatic fibrosis using a pulmonary artery banding (PAB)-induced right heart failure model and investigated whether cardiac output (CO) is responsible for the progression of hepatic fibrosis. Methods and Results: Five-week-old Sprague-Dawley rats divided into the PAB and sham-operated control groups. After 4 weeks from operation, we measured CO by echocardiography, and hepatic fibrosis ratio by pathological examination using a color analyzer. In the PAB group, CO was significantly lower by 48% than that in the control group (78.2±27.6 and 150.1±31.2 ml/min, P

    AB - Background: Hepatic fibrosis progresses with right heart failure, and becomes cardiac cirrhosis in a severe case. Although its causal factor still remains unclear. Here we evaluated the progression of hepatic fibrosis using a pulmonary artery banding (PAB)-induced right heart failure model and investigated whether cardiac output (CO) is responsible for the progression of hepatic fibrosis. Methods and Results: Five-week-old Sprague-Dawley rats divided into the PAB and sham-operated control groups. After 4 weeks from operation, we measured CO by echocardiography, and hepatic fibrosis ratio by pathological examination using a color analyzer. In the PAB group, CO was significantly lower by 48% than that in the control group (78.2±27.6 and 150.1±31.2 ml/min, P

    UR - http://www.scopus.com/inward/record.url?scp=84959420863&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84959420863&partnerID=8YFLogxK

    U2 - 10.1371/journal.pone.0148666

    DO - 10.1371/journal.pone.0148666

    M3 - Article

    C2 - 26863419

    AN - SCOPUS:84959420863

    VL - 11

    JO - PLoS One

    JF - PLoS One

    SN - 1932-6203

    IS - 2

    M1 - e0148666

    ER -