Low cardiac output leads hepatic fibrosis in right heart failure model rats

Yoshitaka Fujimoto, Takashi Urashima, Daisuke Shimura, Reiji Ito, Sadataka Kawachi, Ichige Kajimura, Toru Akaike, Yoichiro Kusakari, Masako Fujiwara, Kiyoshi Ogawa, Nobuhito Goda, Hiroyuki Ida, Susumu Minamisawa

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    Background: Hepatic fibrosis progresses with right heart failure, and becomes cardiac cirrhosis in a severe case. Although its causal factor still remains unclear. Here we evaluated the progression of hepatic fibrosis using a pulmonary artery banding (PAB)-induced right heart failure model and investigated whether cardiac output (CO) is responsible for the progression of hepatic fibrosis. Methods and Results: Five-week-old Sprague-Dawley rats divided into the PAB and sham-operated control groups. After 4 weeks from operation, we measured CO by echocardiography, and hepatic fibrosis ratio by pathological examination using a color analyzer. In the PAB group, CO was significantly lower by 48% than that in the control group (78.2±27.6 and 150.1±31.2 ml/min, P

    Original languageEnglish
    Article numbere0148666
    JournalPLoS One
    Issue number2
    Publication statusPublished - 2016 Feb 1


    ASJC Scopus subject areas

    • Agricultural and Biological Sciences(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Medicine(all)

    Cite this

    Fujimoto, Y., Urashima, T., Shimura, D., Ito, R., Kawachi, S., Kajimura, I., Akaike, T., Kusakari, Y., Fujiwara, M., Ogawa, K., Goda, N., Ida, H., & Minamisawa, S. (2016). Low cardiac output leads hepatic fibrosis in right heart failure model rats. PLoS One, 11(2), [e0148666]. https://doi.org/10.1371/journal.pone.0148666