Low-dose Gamma Knife radiosurgery for cavernous sinus hemangioma: Report of 3 cases and literature review

P. Ivanov, M. Chernov, M. Hayashi, K. Nakaya, M. Izawa, N. Murata, O. Kubo, H. Ujiie, Y. Muragaki, R. Nakamura, Hiroshi Iseki, T. Hori, K. Takakura

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Optimal management of cavernous sinus heman-giomas remains unclear. Total microsurgical removal of these neoplasms may be extremely difficult due to their rich vascularization. Three cases of cavernous sinus hemangioma treated with low-dose Gamma Knife radiosurgery are presented. Marginal dose varied from 10 to 13 Gy. Treatment planning and radiation dosimetry were done with a goal of conformal and selective coverage of the lesion with 50% prescription isodose line using multiisocenter technique. In all cases significant shrinkage of the neoplasm was marked at 3 months after treatment. Mean volume reduction at 12 months after radiosurgery was 60% (range: 45-75%). In all patients the shrinkage of the neoplasm was accompanied by notable improvement of the preexistent oculomotor nerve palsy. No radiosurgery-related complications were met during follow-up. In conclusion, low-dose Gamma Knife radiosurgery seems to be very effective for management of cavernous sinus hemangiomas, and can be considered as a treatment modality of choice for these lesions.

Original languageEnglish
Pages (from-to)140-146
Number of pages7
JournalMinimally Invasive Neurosurgery
Issue number3
Publication statusPublished - 2008 Jun
Externally publishedYes



  • Cavernous sinus hemangioma
  • Gamma knife radiosurgery
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Ivanov, P., Chernov, M., Hayashi, M., Nakaya, K., Izawa, M., Murata, N., Kubo, O., Ujiie, H., Muragaki, Y., Nakamura, R., Iseki, H., Hori, T., & Takakura, K. (2008). Low-dose Gamma Knife radiosurgery for cavernous sinus hemangioma: Report of 3 cases and literature review. Minimally Invasive Neurosurgery, 51(3), 140-146. https://doi.org/10.1055/s-2008-1065346