Low-volume exercise training attenuates oxidative stress and neutrophils activation in older adults

Masaki Takahashi, Masashi Miyashita, Noriaki Kawanishi, Jong Hwan Park, Harumi Hayashida, Hyun Shik Kim, Yoshio Nakamura, Shizuo Sakamoto, Katsuhiko Suzuki

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The purpose of this study was to investigate the effects of low-volume exercise training (100 min/week) on oxidative stress and neutrophils activation markers in older adults. Twenty-eight older adults (age range 65-78 years) were assigned into control (n = 14) or exercise (n = 14) groups. The exercise program consisted of walking 30-60 min/session, 2 days each week for 12 weeks. Blood samples were taken before starting the sessions (baseline) and when they ended. Fasting plasma and serum oxidative stress and inflammatory markers were measured using commercial kits. Cell surface expression of adhesion molecules on circulating leukocytes (CD66b and CD62L) was determined using flow cytometry. The concentrations of derivatives of reactive oxygen metabolites tended to be lower than the baseline values only in the exercise group (P = 0.05). The biological antioxidant potential, thioredoxin concentrations, and glutathione peroxidase activities significantly increased only in the exercise group (P < 0.05 for all). While CD66b expression tended to decrease only in the exercise group, CD62L expression significantly increased (P < 0.05). Our findings indicate that exercise training below the current recommended level of at least 150 min/week attenuates basal oxidative stress and neutrophil activation in older adults. Thus, our findings may encourage more people to incorporate a small amount of physical activity into their lives.

Original languageEnglish
Pages (from-to)1117-1126
Number of pages10
JournalEuropean Journal of Applied Physiology
Volume113
Issue number5
DOIs
Publication statusPublished - 2013 May 1

Keywords

  • Aging
  • CD62L
  • CD66b
  • Derivatives of reactive oxygen metabolites
  • Walking program

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

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