Lowering effects of allyl isothiocyanate on the number of lymphocyte and its subsets in rats

Kazuhiko Imaizumi*, Yuko Sakakibara, Hiromi Sasaki, Shogo Sato, Yumi Takei, Kaori Hiruma, Takamasa Ban, Yu Kawashima, Jun Tanihata, Kaoru Tachiyashiki

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)


    The purpose of this study was to elucidate the effects of a main pungent component of wasabi, allyl isothiocyanate (AITC), on the number of lymphocytes, T-lymphocyte, B-lymphocyte and natural killer (NK) cells and plasma corticosterone concentrations in rats. AITC was given as either single dosage [20mg/kg body weight per day; subcutaneous (s.c.) and oral] or as a daily dosage (10 mg and 20mg/kg body weight per day; s.c.) for 4 days for the hourly and daily assessment of changes in the numbers of lymphocytes, respectively. A single s.c. injection or oral administration of AITC significantly reduced the number of lymphocytes at 4 hr to approximately 0.68 times, indicating that decreased effects of AITC on the number of lymphocytes are independent on the administration route. Administration of AITC for 4 days reduced dose-dependently the number of lymphocytes, and significantly reduced the number of T-lymphocyte and B-lymphocyte to 0.79 and 0.60 times, respectively. However, the number of NK cells did not change by AITC. Administration of AITC increased plasma corticosterone concentrations at 4 day of post s.c. injection to 5.4-6.0 times. These results suggest that AITC-mediated immunosuppresion is at least in part attributable to changes in the number and distribution of lymphocyte and its subsets.

    Original languageEnglish
    Pages (from-to)347-354
    Number of pages8
    JournalJournal of Health Science
    Issue number3
    Publication statusPublished - 2010 Jun


    • Allyl isothiocyanate
    • B-lymphocyte
    • Lymphocyte
    • Natural killer cell
    • T-lymphocyte

    ASJC Scopus subject areas

    • Toxicology
    • Health, Toxicology and Mutagenesis


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