Lowering effects of allyl isothiocyanate on the number of lymphocyte and its subsets in rats

Kazuhiko Imaizumi, Yuko Sakakibara, Hiromi Sasaki, Shogo Sato, Yumi Takei, Kaori Hiruma, Takamasa Ban, Yu Kawashima, Jun Tanihata, Kaoru Tachiyashiki

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    Abstract

    The purpose of this study was to elucidate the effects of a main pungent component of wasabi, allyl isothiocyanate (AITC), on the number of lymphocytes, T-lymphocyte, B-lymphocyte and natural killer (NK) cells and plasma corticosterone concentrations in rats. AITC was given as either single dosage [20mg/kg body weight per day; subcutaneous (s.c.) and oral] or as a daily dosage (10 mg and 20mg/kg body weight per day; s.c.) for 4 days for the hourly and daily assessment of changes in the numbers of lymphocytes, respectively. A single s.c. injection or oral administration of AITC significantly reduced the number of lymphocytes at 4 hr to approximately 0.68 times, indicating that decreased effects of AITC on the number of lymphocytes are independent on the administration route. Administration of AITC for 4 days reduced dose-dependently the number of lymphocytes, and significantly reduced the number of T-lymphocyte and B-lymphocyte to 0.79 and 0.60 times, respectively. However, the number of NK cells did not change by AITC. Administration of AITC increased plasma corticosterone concentrations at 4 day of post s.c. injection to 5.4-6.0 times. These results suggest that AITC-mediated immunosuppresion is at least in part attributable to changes in the number and distribution of lymphocyte and its subsets.

    Original languageEnglish
    Pages (from-to)347-354
    Number of pages8
    JournalJournal of Health Science
    Volume56
    Issue number3
    DOIs
    Publication statusPublished - 2010 Jun

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    Keywords

    • Allyl isothiocyanate
    • B-lymphocyte
    • Lymphocyte
    • Natural killer cell
    • T-lymphocyte

    ASJC Scopus subject areas

    • Toxicology
    • Health, Toxicology and Mutagenesis

    Cite this

    Imaizumi, K., Sakakibara, Y., Sasaki, H., Sato, S., Takei, Y., Hiruma, K., Ban, T., Kawashima, Y., Tanihata, J., & Tachiyashiki, K. (2010). Lowering effects of allyl isothiocyanate on the number of lymphocyte and its subsets in rats. Journal of Health Science, 56(3), 347-354. https://doi.org/10.1248/jhs.56.347