Lung cancer in smoking patients inversely alters the activity of hOGG1 and hNTH1

Zsolt Radak, Sataro Goto, Hideko Nakamoto, Katalin Udud, Zsolt Papai, Ildiko Horvath

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

N-Glycosylases excise the damaged adducts from DNA. 7,8-Dihydro-8- oxoguanine in human cells is repaired by OGG1 and hNTH1. The activities of hOGG1 and hNTH1 were measured, using modified and 32P labelled oligonucleotides, in bronchial biopsy samples of smoking patients with non-small cell lung carcinoma. The activity of hOOG1 was significantly higher in biopsies from tumour tissues compared with intra-individual control samples. On the contrary, the activity of endonuclease III homologue, hNTH1, was lower in tumours compared to controls. These opposing alterations in DNA repair enzymes may affect cancer growth due to the increased formation of AP sites.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalCancer Letters
Volume219
Issue number2
DOIs
Publication statusPublished - 2005 Mar 10
Externally publishedYes

Keywords

  • Base excision repair
  • DNA repair
  • Formamidopyrimidine- DNA
  • Lung cancer
  • Mutation
  • OGG1
  • Smoking
  • hNTH1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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