Lymphatic transport of eicosapentaenoic and docosahexaenoic acids as triglyceride, ethyl ester and free acid, and their effect on cholesterol transport in rats

Ikuo Ikeda, Youji Imasato, Hiroshi Nagao, Eiji Sasaki, Michihiro Sugano, Katsumi Imaizumi, Kazunaga Yazawa

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Lymphatic transport of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids given in the forms of triglyceride, ethyl ester or free acid and their effect on cholesterol transport was compared in lymphcannulated rats. Lymphatic recovery of DHA and EPA given by stomach tube in the form of triglyceride in which they were mainly located at the 2-position was significantly higher than that of the ethyl ester or free acid during the first 6 hr after the administration and the tendency continued until 9 hr. In contrast, the 9 to 24 hr recovery of DHA and EPA in the forms of ethyl ester and free acid was considerably higher than that of triglyceride. Consequently, cumulative 24 hr recovery EPA was comparable among the three forms. However, the 24 hr recovery of DHA was highest in free acid, lowest in ethyl ester and intermediate in triglyceride. Recovery of the free acid between 9 and 24 hr after administration was significantly higher than that given in the forms of triglyceride or ethyl ester. Cholesterol recovery in lymph of rats given with ethyl ester or free acid was lower than that given with triglyceride at an early stage after the administration in both EPA and DHA. Cumulative 24 hr recovery of cholesterol in rats given these fatty acids as ethyl ester was significantly lower than in those given as the other two forms.

Original languageEnglish
Pages (from-to)1371-1379
Number of pages9
JournalLife Sciences
Volume52
Issue number16
DOIs
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Eicosapentaenoic Acid
Docosahexaenoic Acids
Rats
Esters
Triglycerides
Cholesterol
Recovery
Acids
Lymph
Stomach
Fatty Acids

ASJC Scopus subject areas

  • Pharmacology

Cite this

Lymphatic transport of eicosapentaenoic and docosahexaenoic acids as triglyceride, ethyl ester and free acid, and their effect on cholesterol transport in rats. / Ikeda, Ikuo; Imasato, Youji; Nagao, Hiroshi; Sasaki, Eiji; Sugano, Michihiro; Imaizumi, Katsumi; Yazawa, Kazunaga.

In: Life Sciences, Vol. 52, No. 16, 1993, p. 1371-1379.

Research output: Contribution to journalArticle

Ikeda, Ikuo ; Imasato, Youji ; Nagao, Hiroshi ; Sasaki, Eiji ; Sugano, Michihiro ; Imaizumi, Katsumi ; Yazawa, Kazunaga. / Lymphatic transport of eicosapentaenoic and docosahexaenoic acids as triglyceride, ethyl ester and free acid, and their effect on cholesterol transport in rats. In: Life Sciences. 1993 ; Vol. 52, No. 16. pp. 1371-1379.
@article{cfc1f79b3fd549e49dba85269d9740fa,
title = "Lymphatic transport of eicosapentaenoic and docosahexaenoic acids as triglyceride, ethyl ester and free acid, and their effect on cholesterol transport in rats",
abstract = "Lymphatic transport of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids given in the forms of triglyceride, ethyl ester or free acid and their effect on cholesterol transport was compared in lymphcannulated rats. Lymphatic recovery of DHA and EPA given by stomach tube in the form of triglyceride in which they were mainly located at the 2-position was significantly higher than that of the ethyl ester or free acid during the first 6 hr after the administration and the tendency continued until 9 hr. In contrast, the 9 to 24 hr recovery of DHA and EPA in the forms of ethyl ester and free acid was considerably higher than that of triglyceride. Consequently, cumulative 24 hr recovery EPA was comparable among the three forms. However, the 24 hr recovery of DHA was highest in free acid, lowest in ethyl ester and intermediate in triglyceride. Recovery of the free acid between 9 and 24 hr after administration was significantly higher than that given in the forms of triglyceride or ethyl ester. Cholesterol recovery in lymph of rats given with ethyl ester or free acid was lower than that given with triglyceride at an early stage after the administration in both EPA and DHA. Cumulative 24 hr recovery of cholesterol in rats given these fatty acids as ethyl ester was significantly lower than in those given as the other two forms.",
author = "Ikuo Ikeda and Youji Imasato and Hiroshi Nagao and Eiji Sasaki and Michihiro Sugano and Katsumi Imaizumi and Kazunaga Yazawa",
year = "1993",
doi = "10.1016/0024-3205(93)90172-Y",
language = "English",
volume = "52",
pages = "1371--1379",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "16",

}

TY - JOUR

T1 - Lymphatic transport of eicosapentaenoic and docosahexaenoic acids as triglyceride, ethyl ester and free acid, and their effect on cholesterol transport in rats

AU - Ikeda, Ikuo

AU - Imasato, Youji

AU - Nagao, Hiroshi

AU - Sasaki, Eiji

AU - Sugano, Michihiro

AU - Imaizumi, Katsumi

AU - Yazawa, Kazunaga

PY - 1993

Y1 - 1993

N2 - Lymphatic transport of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids given in the forms of triglyceride, ethyl ester or free acid and their effect on cholesterol transport was compared in lymphcannulated rats. Lymphatic recovery of DHA and EPA given by stomach tube in the form of triglyceride in which they were mainly located at the 2-position was significantly higher than that of the ethyl ester or free acid during the first 6 hr after the administration and the tendency continued until 9 hr. In contrast, the 9 to 24 hr recovery of DHA and EPA in the forms of ethyl ester and free acid was considerably higher than that of triglyceride. Consequently, cumulative 24 hr recovery EPA was comparable among the three forms. However, the 24 hr recovery of DHA was highest in free acid, lowest in ethyl ester and intermediate in triglyceride. Recovery of the free acid between 9 and 24 hr after administration was significantly higher than that given in the forms of triglyceride or ethyl ester. Cholesterol recovery in lymph of rats given with ethyl ester or free acid was lower than that given with triglyceride at an early stage after the administration in both EPA and DHA. Cumulative 24 hr recovery of cholesterol in rats given these fatty acids as ethyl ester was significantly lower than in those given as the other two forms.

AB - Lymphatic transport of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids given in the forms of triglyceride, ethyl ester or free acid and their effect on cholesterol transport was compared in lymphcannulated rats. Lymphatic recovery of DHA and EPA given by stomach tube in the form of triglyceride in which they were mainly located at the 2-position was significantly higher than that of the ethyl ester or free acid during the first 6 hr after the administration and the tendency continued until 9 hr. In contrast, the 9 to 24 hr recovery of DHA and EPA in the forms of ethyl ester and free acid was considerably higher than that of triglyceride. Consequently, cumulative 24 hr recovery EPA was comparable among the three forms. However, the 24 hr recovery of DHA was highest in free acid, lowest in ethyl ester and intermediate in triglyceride. Recovery of the free acid between 9 and 24 hr after administration was significantly higher than that given in the forms of triglyceride or ethyl ester. Cholesterol recovery in lymph of rats given with ethyl ester or free acid was lower than that given with triglyceride at an early stage after the administration in both EPA and DHA. Cumulative 24 hr recovery of cholesterol in rats given these fatty acids as ethyl ester was significantly lower than in those given as the other two forms.

UR - http://www.scopus.com/inward/record.url?scp=0027411287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027411287&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(93)90172-Y

DO - 10.1016/0024-3205(93)90172-Y

M3 - Article

VL - 52

SP - 1371

EP - 1379

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 16

ER -