Abstract
To better understand dermal response to visible light, we used DNA microarray analysis to search genes induced by blue or near-UV light in normal human dermal fibroblasts. Of about 12 800 transcripts analyzed, near-UV light most prominently upregulated the transcript level of Mic-1, a gene encoding a TGF-β superfamily protein. Quantitative RT-PCR and immunoblot analyses revealed that mRNA and protein levels of Mic-1 were upregulated by both short-wavelength light but not by green or red light. These results suggest that the human dermis is a site for macrophage inhibitory cytokine-1 (MIC-1) production and that visible light activates a dermal transcription cascade. Considering the role of MIC-1 in immune regulation and appetite control, photic MIC-1 regulation is of physiological importance.
Original language | English |
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Pages (from-to) | 933-937 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 583 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2009 Mar 4 |
Keywords
- Blue light
- Dermal fibroblast
- MIC-1
- Microarray
- Near-UV light
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology