Magnetic driven alginate nanoparticles for targeted drug delivery

Gianni Ciofani, Vittoria Raffa, Yosuke Obata, Arianna Menciassi, Paolo Dario, Shinji Takeoka

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    The aim of this paper is to develop highly magnetized, biodegradable and biocompatible, polymeric nanoparticles for drug delivery intell therapy. Alginate magnetic nanoparticles are realized by an emulsion/reticulation technique, after the dispersion of magnetite in an alginate solution. Such nanoparticles are characterized in terms of external morphology (FIB imaging), microstructure (TEM imaging), size distribution, zeta potential, magnetic properties (SQUID analysis) and drug release behaviour. Magnetization curves hsow the typical trend of superparamagnetic materials. Important parameters, such as magnetic permeability and magnetic momentum, are derived by employing Langevin theory. Experimental results reveal that a bi-exponential model fully describes the drug release. Finally, in vitro experiments on NIH/3T3 cells are carried out and demonstrate that our magnetic alginate nanoparticles can effectively drive the drug delivery towards an external magnetic field source.

    Original languageEnglish
    Pages (from-to)212-218
    Number of pages7
    JournalCurrent Nanoscience
    Volume4
    Issue number2
    DOIs
    Publication statusPublished - 2008 May

    Fingerprint

    Alginate
    Nanoparticles
    Drug delivery
    Pharmaceutical Preparations
    Ferrosoferric Oxide
    Imaging techniques
    Magnetic permeability
    NIH 3T3 Cells
    SQUIDs
    Magnetite
    Zeta potential
    Magnetic Fields
    Emulsions
    Permeability
    Magnetization
    Magnetic properties
    Momentum
    Magnetic fields
    Transmission electron microscopy
    Microstructure

    Keywords

    • Alginate nanoparticles
    • Drug delivery system
    • Magnetic driven drug delivery
    • Magnetic nanoparticles

    ASJC Scopus subject areas

    • Biotechnology
    • Pharmaceutical Science

    Cite this

    Magnetic driven alginate nanoparticles for targeted drug delivery. / Ciofani, Gianni; Raffa, Vittoria; Obata, Yosuke; Menciassi, Arianna; Dario, Paolo; Takeoka, Shinji.

    In: Current Nanoscience, Vol. 4, No. 2, 05.2008, p. 212-218.

    Research output: Contribution to journalArticle

    Ciofani, G, Raffa, V, Obata, Y, Menciassi, A, Dario, P & Takeoka, S 2008, 'Magnetic driven alginate nanoparticles for targeted drug delivery', Current Nanoscience, vol. 4, no. 2, pp. 212-218. https://doi.org/10.2174/157341308784340886
    Ciofani, Gianni ; Raffa, Vittoria ; Obata, Yosuke ; Menciassi, Arianna ; Dario, Paolo ; Takeoka, Shinji. / Magnetic driven alginate nanoparticles for targeted drug delivery. In: Current Nanoscience. 2008 ; Vol. 4, No. 2. pp. 212-218.
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