Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model

Shotaro Yasuda; Sho Higano; Atsushi Ishiyama; Yumie Ono; Ichige Kajimura; Susumu Minamisawa

doi:10.1109/EMBC.2015.7319388

Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model

Shotaro Yasuda, Sho Higano, Atsushi Ishiyama, Yumie Ono, Ichige Kajimura, Susumu Minamisawa

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Utilizing small animal magnetocardiograms (MCG), we have developed a diagnostic method to detect the development of pulmonary hypertension (PH) in a rat heart. We obtained multiple MCG of rats with monocrotaline-induced PH and monitored the development of pathophysiological conditions. Current dipole estimation was then applied to determine the association between abnormal propagation of the cardiac excited wavefront and disease states. The progress of right ventricular hypertrophy correlated with a decrease in the angles of the current dipoles during R and S waves. In addition, clear changes in the current dipole angles during S waves were observed 9-19 days before the availability of echocardiographic diagnosis of the PH. Our results showed, using a rat PH model, that continuous monitoring of myocardial conditions allows PH to be detected at an earlier stage than echocardiographic screening.

Original language	English
Title of host publication	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	4475-4478
Number of pages	4
Volume	2015-November
ISBN (Print)	9781424492718
DOIs	https://doi.org/10.1109/EMBC.2015.7319388
Publication status	Published - 2015 Nov 4
Event	37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy Duration: 2015 Aug 25 → 2015 Aug 29

Other

Other	37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Country/Territory	Italy
City	Milan
Period	15/8/25 → 15/8/29

ASJC Scopus subject areas

Computer Vision and Pattern Recognition
Signal Processing
Biomedical Engineering
Health Informatics

Access to Document

10.1109/EMBC.2015.7319388

Cite this

Yasuda, S., Higano, S., Ishiyama, A., Ono, Y., Kajimura, I., & Minamisawa, S. (2015). Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2015-November, pp. 4475-4478). [7319388] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7319388

Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model. / Yasuda, Shotaro; Higano, Sho; Ishiyama, Atsushi et al.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. p. 4475-4478 7319388.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Yasuda, S, Higano, S, Ishiyama, A, Ono, Y, Kajimura, I & Minamisawa, S 2015, Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. vol. 2015-November, 7319388, Institute of Electrical and Electronics Engineers Inc., pp. 4475-4478, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 15/8/25. https://doi.org/10.1109/EMBC.2015.7319388

Yasuda S, Higano S, Ishiyama A, Ono Y, Kajimura I, Minamisawa S. Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November. Institute of Electrical and Electronics Engineers Inc. 2015. p. 4475-4478. 7319388 doi: 10.1109/EMBC.2015.7319388

Yasuda, Shotaro ; Higano, Sho ; Ishiyama, Atsushi et al. / Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. pp. 4475-4478

@inproceedings{a7cd174064b945bdb60173de76c38c2a,

title = "Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model",

abstract = "Utilizing small animal magnetocardiograms (MCG), we have developed a diagnostic method to detect the development of pulmonary hypertension (PH) in a rat heart. We obtained multiple MCG of rats with monocrotaline-induced PH and monitored the development of pathophysiological conditions. Current dipole estimation was then applied to determine the association between abnormal propagation of the cardiac excited wavefront and disease states. The progress of right ventricular hypertrophy correlated with a decrease in the angles of the current dipoles during R and S waves. In addition, clear changes in the current dipole angles during S waves were observed 9-19 days before the availability of echocardiographic diagnosis of the PH. Our results showed, using a rat PH model, that continuous monitoring of myocardial conditions allows PH to be detected at an earlier stage than echocardiographic screening.",

author = "Shotaro Yasuda and Sho Higano and Atsushi Ishiyama and Yumie Ono and Ichige Kajimura and Susumu Minamisawa",

year = "2015",

month = nov,

day = "4",

doi = "10.1109/EMBC.2015.7319388",

language = "English",

isbn = "9781424492718",

volume = "2015-November",

pages = "4475--4478",

booktitle = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 ; Conference date: 25-08-2015 Through 29-08-2015",

}

TY - GEN

T1 - Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model

AU - Yasuda, Shotaro

AU - Higano, Sho

AU - Ishiyama, Atsushi

AU - Ono, Yumie

AU - Kajimura, Ichige

AU - Minamisawa, Susumu

PY - 2015/11/4

Y1 - 2015/11/4

N2 - Utilizing small animal magnetocardiograms (MCG), we have developed a diagnostic method to detect the development of pulmonary hypertension (PH) in a rat heart. We obtained multiple MCG of rats with monocrotaline-induced PH and monitored the development of pathophysiological conditions. Current dipole estimation was then applied to determine the association between abnormal propagation of the cardiac excited wavefront and disease states. The progress of right ventricular hypertrophy correlated with a decrease in the angles of the current dipoles during R and S waves. In addition, clear changes in the current dipole angles during S waves were observed 9-19 days before the availability of echocardiographic diagnosis of the PH. Our results showed, using a rat PH model, that continuous monitoring of myocardial conditions allows PH to be detected at an earlier stage than echocardiographic screening.

AB - Utilizing small animal magnetocardiograms (MCG), we have developed a diagnostic method to detect the development of pulmonary hypertension (PH) in a rat heart. We obtained multiple MCG of rats with monocrotaline-induced PH and monitored the development of pathophysiological conditions. Current dipole estimation was then applied to determine the association between abnormal propagation of the cardiac excited wavefront and disease states. The progress of right ventricular hypertrophy correlated with a decrease in the angles of the current dipoles during R and S waves. In addition, clear changes in the current dipole angles during S waves were observed 9-19 days before the availability of echocardiographic diagnosis of the PH. Our results showed, using a rat PH model, that continuous monitoring of myocardial conditions allows PH to be detected at an earlier stage than echocardiographic screening.

UR - http://www.scopus.com/inward/record.url?scp=84953268992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84953268992&partnerID=8YFLogxK

U2 - 10.1109/EMBC.2015.7319388

DO - 10.1109/EMBC.2015.7319388

M3 - Conference contribution

C2 - 26737288

AN - SCOPUS:84953268992

SN - 9781424492718

VL - 2015-November

SP - 4475

EP - 4478

BT - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015

Y2 - 25 August 2015 through 29 August 2015

ER -

Magnetocardiograms early detection of pulmonary arterial hypertension using inverse problem analysis in rat model

Abstract

Other

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this