Mangromicins A and B: Structure and antitrypanosomal activity of two new cyclopentadecane compounds from Lechevalieria aerocolonigenes K10-0216

Takuji Nakashima, Masato Iwatsuki, Junya Ochiai, Yoshiyuki Kamiya, Kenichiro Nagai, Atsuko Matsumoto, Aki Ishiyama, Kazuhiko Otoguro, Kazuro Shiomi, Yoko Takahashi, Satoshi Omura

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Two new cyclopentadecane antibiotics, named mangromicins A and B, were separated out from the culture broth of Lechevalieria aerocolonigenes K10-0216 by Diaion HP-20, silica gel and ODS column chromatography, and were finally purified by HPLC. The chemical structures of the two novel compounds were elucidated by instrumental analyses, including various NMR, MS and X-ray crystallography. Mangromicins A and B consist of cyclopentadecane skeletons with a tetrahydrofuran unit and a 5,6-dihydro-4-hydroxy-2-pyrone moiety. Mangromicins A and B showed in vitro antitrypanosomal activity with IC 50 values of 2.4 and 43.4 μg ml -1, respectively. The IC 50 values of both compounds were lower than those of cytotoxicity against MRC-5 human fetal lung fibroblast cells.

Original languageEnglish
Pages (from-to)253-260
Number of pages8
JournalJournal of Antibiotics
Volume67
Issue number3
DOIs
Publication statusPublished - 2014 Mar
Externally publishedYes

Keywords

  • Antitrypanosomal activity
  • Lechevalieria aerocolonigenes
  • Mangromicins
  • Mangrove sediment
  • Physicochemical screening

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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