Marine Metagenome as A Resource for Novel Enzymes

Amani D. Alma'abadi, Takashi Gojobori*, Katsuhiko Mineta

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)

Abstract

More than 99% of identified prokaryotes, including many from the marine environment, cannot be cultured in the laboratory. This lack of capability restricts our knowledge of microbial genetics and community ecology. Metagenomics, the culture-independent cloning of environmental DNAs that are isolated directly from an environmental sample, has already provided a wealth of information about the uncultured microbial world. It has also facilitated the discovery of novel biocatalysts by allowing researchers to probe directly into a huge diversity of enzymes within natural microbial communities. Recent advances in these studies have led to a great interest in recruiting microbial enzymes for the development of environmentally-friendly industry. Although the metagenomics approach has many limitations, it is expected to provide not only scientific insights but also economic benefits, especially in industry. This review highlights the importance of metagenomics in mining microbial lipases, as an example, by using high-throughput techniques. In addition, we discuss challenges in the metagenomics as an important part of bioinformatics analysis in big data.

Original languageEnglish
Pages (from-to)290-295
Number of pages6
JournalGenomics, Proteomics and Bioinformatics
Volume13
Issue number5
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Biotechnology
  • Catalysis
  • Culture-independent studies
  • Lipase
  • Microbial diversity

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Computational Mathematics

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