Marine pharmacology in 2014-2015: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, antiviral, and anthelmintic activities; Affecting the immune and nervous systems, and othermiscellaneousmechanisms of action

Alejandro M.S. Mayer, Aimee J. Guerrero, Abimael D. Rodríguez, Orazio Taglialatela-Scafati, Fumiaki Nakamura, Nobuhiro Fusetani

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

The systematic review of the marine pharmacology literature from 2014 to 2015 was completed in a manner consistent with the 1998-2013 reviews of this series. Research in marine pharmacology during 2014-2015, which was reported by investigators in 43 countries, described novel findings on the preclinical pharmacology of 301 marine compounds. These observations included antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic pharmacological activities for 133 marine natural products, 85 marine compounds with antidiabetic, and anti-inflammatory activities, as well as those that affected the immune and nervous system, and 83 marine compounds that displayed miscellaneous mechanisms of action, and may probably contribute to novel pharmacological classes upon further research. Thus, in 2014-2015, the preclinical marine natural product pharmacology pipeline provided novel pharmacology as well as new lead compounds for the clinical marine pharmaceutical pipeline, and thus continued to contribute to ongoing global research for alternative therapeutic approaches to many disease categories.

Original languageEnglish
Article number5
JournalMarine Drugs
Volume18
Issue number1
DOIs
Publication statusPublished - 2020

Keywords

  • Chemical
  • Drug
  • Marine
  • Metabolite
  • Natural product
  • Pharmaceutical
  • Pharmacology
  • Pipeline
  • Review
  • Toxicology

ASJC Scopus subject areas

  • Drug Discovery

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