Massive Fabrication of Polymer Microdiscs by Phase Separation and Freestanding Process

Hong Zhang, Mao Fujii, Yosuke Okamura, Li Zhang, Shinji Takeoka

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We present a facile method to fabricate polymer thin films with tens of nanometers thickness and several micrometers size (also called "microdiscs" herein) by applying phase separation of polymer blend. A water-soluble supporting layer is employed to obtain a freestanding microdisc suspension. Owing to their miniaturized size, microdiscs can be injected through a syringe needle. Herein, poly(d,l-lactic acid) microdiscs were fabricated with various thicknesses and sizes, in the range from ca. 10 to 60 nm and from ca. 1.0 to 10.0 μm, respectively. Magnetic nanoparticles were deposited on polymer microdiscs with a surface coating method. The magnetic manipulation of microdiscs in a liquid environment under an external magnetic field was achieved with controllable velocity by adjusting the microdisc dimensions and the loading amount of magnetic components. Such biocompatible polymer microdiscs are expected to serve as injectable vehicles for targeted drug delivery.

Original languageEnglish
Pages (from-to)16296-16302
Number of pages7
JournalACS Applied Materials and Interfaces
Volume8
Issue number25
DOIs
Publication statusPublished - 2016 Jun 29

Keywords

  • freestanding
  • magnetic manipulation
  • microdisc
  • phase separation
  • polymer blend

ASJC Scopus subject areas

  • Materials Science(all)

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