Massive Fabrication of Polymer Microdiscs by Phase Separation and Freestanding Process

Hong Zhang, Mao Fujii, Yosuke Okamura, Li Zhang, Shinji Takeoka

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    We present a facile method to fabricate polymer thin films with tens of nanometers thickness and several micrometers size (also called "microdiscs" herein) by applying phase separation of polymer blend. A water-soluble supporting layer is employed to obtain a freestanding microdisc suspension. Owing to their miniaturized size, microdiscs can be injected through a syringe needle. Herein, poly(d,l-lactic acid) microdiscs were fabricated with various thicknesses and sizes, in the range from ca. 10 to 60 nm and from ca. 1.0 to 10.0 μm, respectively. Magnetic nanoparticles were deposited on polymer microdiscs with a surface coating method. The magnetic manipulation of microdiscs in a liquid environment under an external magnetic field was achieved with controllable velocity by adjusting the microdisc dimensions and the loading amount of magnetic components. Such biocompatible polymer microdiscs are expected to serve as injectable vehicles for targeted drug delivery.

    Original languageEnglish
    Pages (from-to)16296-16302
    Number of pages7
    JournalACS Applied Materials and Interfaces
    Volume8
    Issue number25
    DOIs
    Publication statusPublished - 2016 Jun 29

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    Keywords

    • freestanding
    • magnetic manipulation
    • microdisc
    • phase separation
    • polymer blend

    ASJC Scopus subject areas

    • Materials Science(all)

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