Mathematical model for cell competition: Predator-prey interactions at the interface between two groups of cells in monolayer tissue

Seiya Nishikawa, Atsuko Takamatsu, Shizue Ohsawa, Tatsushi Igaki

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The phenomenon of 'cell competition' has been implicated in the normal development and maintenance of organs, such as in the regulation of organ size and suppression of neoplastic development. In cell competition, one group of cells competes with another group through an interaction at their interface. Which cell group "wins" is governed by a certain relative fitness within the cells. However, this idea of cellular fitness has not been clearly defined. We construct two types of mathematical models to describe this phenomenon of cell competition by considering the interaction at the interface as a predator-prey type interaction in a monolayer tissue such as epithelium. Both of these models can reproduce several typical experimental observations involving systems of mutant cells (losers) and normal cells (winners). By analyzing one of the model and defining an index for the degree of fitness in groups of cells, we show that the fate of each group mainly depends on the relative carrying capacities of certain resources and the strength of the predator-prey interaction at the interface. This contradicts the classical hypothesis in which the relative proliferation rate determines the winner.

Original languageEnglish
Pages (from-to)40-50
Number of pages11
JournalJournal of Theoretical Biology
Volume404
DOIs
Publication statusPublished - 2016 Sep 7

Keywords

  • Drosophila
  • Group fitness
  • Individual cell-based model
  • Population model
  • Tumor suppression

ASJC Scopus subject areas

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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