Abstract
The phenomenon of 'cell competition' has been implicated in the normal development and maintenance of organs, such as in the regulation of organ size and suppression of neoplastic development. In cell competition, one group of cells competes with another group through an interaction at their interface. Which cell group "wins" is governed by a certain relative fitness within the cells. However, this idea of cellular fitness has not been clearly defined. We construct two types of mathematical models to describe this phenomenon of cell competition by considering the interaction at the interface as a predator-prey type interaction in a monolayer tissue such as epithelium. Both of these models can reproduce several typical experimental observations involving systems of mutant cells (losers) and normal cells (winners). By analyzing one of the model and defining an index for the degree of fitness in groups of cells, we show that the fate of each group mainly depends on the relative carrying capacities of certain resources and the strength of the predator-prey interaction at the interface. This contradicts the classical hypothesis in which the relative proliferation rate determines the winner.
| Original language | English |
|---|---|
| Pages (from-to) | 40-50 |
| Number of pages | 11 |
| Journal | Journal of Theoretical Biology |
| Volume | 404 |
| DOIs | |
| Publication status | Published - 2016 Sep 7 |
Fingerprint
Keywords
- Drosophila
- Group fitness
- Individual cell-based model
- Population model
- Tumor suppression
ASJC Scopus subject areas
- Applied Mathematics
- Statistics and Probability
- Modelling and Simulation
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Medicine(all)
Cite this
Mathematical model for cell competition : Predator-prey interactions at the interface between two groups of cells in monolayer tissue. / Nishikawa, Seiya; Takamatsu, Atsuko; Ohsawa, Shizue; Igaki, Tatsushi.
In: Journal of Theoretical Biology, Vol. 404, 07.09.2016, p. 40-50.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mathematical model for cell competition
T2 - Predator-prey interactions at the interface between two groups of cells in monolayer tissue
AU - Nishikawa, Seiya
AU - Takamatsu, Atsuko
AU - Ohsawa, Shizue
AU - Igaki, Tatsushi
PY - 2016/9/7
Y1 - 2016/9/7
N2 - The phenomenon of 'cell competition' has been implicated in the normal development and maintenance of organs, such as in the regulation of organ size and suppression of neoplastic development. In cell competition, one group of cells competes with another group through an interaction at their interface. Which cell group "wins" is governed by a certain relative fitness within the cells. However, this idea of cellular fitness has not been clearly defined. We construct two types of mathematical models to describe this phenomenon of cell competition by considering the interaction at the interface as a predator-prey type interaction in a monolayer tissue such as epithelium. Both of these models can reproduce several typical experimental observations involving systems of mutant cells (losers) and normal cells (winners). By analyzing one of the model and defining an index for the degree of fitness in groups of cells, we show that the fate of each group mainly depends on the relative carrying capacities of certain resources and the strength of the predator-prey interaction at the interface. This contradicts the classical hypothesis in which the relative proliferation rate determines the winner.
AB - The phenomenon of 'cell competition' has been implicated in the normal development and maintenance of organs, such as in the regulation of organ size and suppression of neoplastic development. In cell competition, one group of cells competes with another group through an interaction at their interface. Which cell group "wins" is governed by a certain relative fitness within the cells. However, this idea of cellular fitness has not been clearly defined. We construct two types of mathematical models to describe this phenomenon of cell competition by considering the interaction at the interface as a predator-prey type interaction in a monolayer tissue such as epithelium. Both of these models can reproduce several typical experimental observations involving systems of mutant cells (losers) and normal cells (winners). By analyzing one of the model and defining an index for the degree of fitness in groups of cells, we show that the fate of each group mainly depends on the relative carrying capacities of certain resources and the strength of the predator-prey interaction at the interface. This contradicts the classical hypothesis in which the relative proliferation rate determines the winner.
KW - Drosophila
KW - Group fitness
KW - Individual cell-based model
KW - Population model
KW - Tumor suppression
UR - http://www.scopus.com/inward/record.url?scp=84971300439&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84971300439&partnerID=8YFLogxK
U2 - 10.1016/j.jtbi.2016.05.031
DO - 10.1016/j.jtbi.2016.05.031
M3 - Article
VL - 404
SP - 40
EP - 50
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
SN - 0022-5193
ER -