Measurement of inferior vena cava diameter for evaluation of venous return in subjects on day 10 of a bed-rest experiment

Yuko Ishizaki, Hideoki Fukuoka, Tatsuro Ishizaki, Minoru Kino, Hirohiko Higashino, Nobuo Ueda, Yuri Fujii, Yohnosuke Kobayashi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We evaluated the usefulness of measurements of the inferior vena cava (IVC) diameters on abdominal echograms as an indicator of changes of venous return in subjects with orthostatic intolerance (OI) induced by simulated microgravity. We performed a standing test and recorded the IVC diameters on abdominal echograms in 12 subjects placed on a 20-day 6° head-down-tilt bed-rest experiment. We found that different patterns of changes in IVC diameter occurred in the standing test on day 10 of the experiment; in five subjects with a marginal decrease in pulse pressure, IVC diameters in the upright position were markedly decreased compared with those in the supine position. In five subjects with feelings of discomfort, the IVC diameters in the upright position distended or did not decrease from those in the supine position. These results suggested that the changes in IVC diameter on the standing test indicated the presence of various types of hemodynamic responses of OI caused by simulated microgravity. In this study, we also evaluated changes in body-water compartments by conducting multifrequency bioelectrical impedance analysis. Longitudinal data analysis showed that the total body-water-to-fat-free mass and extracellular fluid-to-fat-free mass ratios decreased during the experimental period and recovered thereafter, and that the ratio of intracellular fluid to fat-free mass decreased during the experiment. No significant difference in changes in body-water compartments was seen among subjects with different patterns of changes in IVC diameters. Measurement of IVC diameter was useful to estimate hemodynamic changes in subjects with OI.

Original languageEnglish
Pages (from-to)2179-2186
Number of pages8
JournalJournal of Applied Physiology
Volume96
Issue number6
DOIs
Publication statusPublished - 2004 Jun
Externally publishedYes

Fingerprint

Bed Rest
Inferior Vena Cava
Orthostatic Intolerance
Body Water
Weightlessness
Supine Position
Fats
Hemodynamics
Intracellular Fluid
Head-Down Tilt
Extracellular Fluid
Electric Impedance
Emotions
Blood Pressure

Keywords

  • Abdominal echograms
  • Body-water compartments
  • Head-down-tilt
  • Orthostatic intolerance

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Measurement of inferior vena cava diameter for evaluation of venous return in subjects on day 10 of a bed-rest experiment. / Ishizaki, Yuko; Fukuoka, Hideoki; Ishizaki, Tatsuro; Kino, Minoru; Higashino, Hirohiko; Ueda, Nobuo; Fujii, Yuri; Kobayashi, Yohnosuke.

In: Journal of Applied Physiology, Vol. 96, No. 6, 06.2004, p. 2179-2186.

Research output: Contribution to journalArticle

Ishizaki, Y, Fukuoka, H, Ishizaki, T, Kino, M, Higashino, H, Ueda, N, Fujii, Y & Kobayashi, Y 2004, 'Measurement of inferior vena cava diameter for evaluation of venous return in subjects on day 10 of a bed-rest experiment', Journal of Applied Physiology, vol. 96, no. 6, pp. 2179-2186. https://doi.org/10.1152/japplphysiol.01097.2003
Ishizaki, Yuko ; Fukuoka, Hideoki ; Ishizaki, Tatsuro ; Kino, Minoru ; Higashino, Hirohiko ; Ueda, Nobuo ; Fujii, Yuri ; Kobayashi, Yohnosuke. / Measurement of inferior vena cava diameter for evaluation of venous return in subjects on day 10 of a bed-rest experiment. In: Journal of Applied Physiology. 2004 ; Vol. 96, No. 6. pp. 2179-2186.
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