Measurement of nuclear reaction cross sections by using Cherenkov radiation toward high-precision proton therapy

Takamitsu Masuda, Jun Kataoka, Makoto Arimoto, Miho Takabe, Teiji Nishio, Keiichiro Matsushita, Tasuku Miyake, Seiichi Yamamoto, Taku Inaniwa, Toshiyuki Toshito

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    Monitoring the in vivo dose distribution in proton therapy is desirable for the accurate irradiation of a tumor. Although positron emission tomography (PET) is widely used for confirmation, the obtained distribution of positron emitters produced by the protons does not trace the dose distribution due to the different physical processes. To estimate the accurate dose from the PET image, the cross sections of nuclear reactions that produce positron emitters are important yet far from being sufficient. In this study, we measured the cross sections of 16O(p,x)15O, 16O(p,x)13N, and 16O(p,x)11C with a wide-energy range (approximately 5-70 MeV) by observing the temporal evolution of the Cherenkov radiation emitted from positrons generated via β + decay along the proton path. Furthermore, we implemented the new cross sectional data into a conventional Monte Carlo (MC) simulation, so that a direct comparison was possible with the PET measurement. We confirmed that our MC results showed good agreement with the experimental data, both in terms of the spatial distributions and temporal evolutions. Although this is the first attempt at using the Cherenkov radiation in the measurements of nuclear cross sections, the obtained results suggest the method is convenient and widely applicable for high precision proton therapy.

    Original languageEnglish
    Article number2570
    JournalScientific Reports
    Volume8
    Issue number1
    DOIs
    Publication statusPublished - 2018 Dec 1

    Fingerprint

    nuclear reactions
    therapy
    positrons
    protons
    cross sections
    radiation
    tomography
    dosage
    emitters
    spatial distribution
    tumors
    irradiation
    decay
    estimates
    simulation
    energy

    ASJC Scopus subject areas

    • General

    Cite this

    Measurement of nuclear reaction cross sections by using Cherenkov radiation toward high-precision proton therapy. / Masuda, Takamitsu; Kataoka, Jun; Arimoto, Makoto; Takabe, Miho; Nishio, Teiji; Matsushita, Keiichiro; Miyake, Tasuku; Yamamoto, Seiichi; Inaniwa, Taku; Toshito, Toshiyuki.

    In: Scientific Reports, Vol. 8, No. 1, 2570, 01.12.2018.

    Research output: Contribution to journalArticle

    Masuda, T, Kataoka, J, Arimoto, M, Takabe, M, Nishio, T, Matsushita, K, Miyake, T, Yamamoto, S, Inaniwa, T & Toshito, T 2018, 'Measurement of nuclear reaction cross sections by using Cherenkov radiation toward high-precision proton therapy', Scientific Reports, vol. 8, no. 1, 2570. https://doi.org/10.1038/s41598-018-20906-z
    Masuda, Takamitsu ; Kataoka, Jun ; Arimoto, Makoto ; Takabe, Miho ; Nishio, Teiji ; Matsushita, Keiichiro ; Miyake, Tasuku ; Yamamoto, Seiichi ; Inaniwa, Taku ; Toshito, Toshiyuki. / Measurement of nuclear reaction cross sections by using Cherenkov radiation toward high-precision proton therapy. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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