TY - JOUR
T1 - Measurement of the bio-mechanical properties of two different feeder layer cells
AU - Romanazzo, S.
AU - Uesugi, K.
AU - Taniguchi, A.
AU - Forte, G.
AU - Morishima, K.
N1 - Funding Information:
The present work was partly supported by the European Regional Development Fund - Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123) to Giancarlo Forte.
Publisher Copyright:
© 2021 Romanazzo et al.
PY - 2021
Y1 - 2021
N2 - Introduction: We here present our findings on 2 types of feeder layers, one composed of mouse embryonic fibroblasts (MEF) and the second one of mouse skeletal myoblasts (C2Cl2) feeder cells. Methods: The 2 feeder layers present a dramatic variance of intrinsic stiffness (142.68 ± 17.21 KPa and 45.78 ± 9.81 KPa, respectively). Results and Conclusion: This information could be used for a better understanding of cells and cell microenvironment mechano-physical characteristics that are influencing stem cell commitment, in order to develop a suitable engineered tissue for cardiac and skeletal muscle repair and a bio-actuator.
AB - Introduction: We here present our findings on 2 types of feeder layers, one composed of mouse embryonic fibroblasts (MEF) and the second one of mouse skeletal myoblasts (C2Cl2) feeder cells. Methods: The 2 feeder layers present a dramatic variance of intrinsic stiffness (142.68 ± 17.21 KPa and 45.78 ± 9.81 KPa, respectively). Results and Conclusion: This information could be used for a better understanding of cells and cell microenvironment mechano-physical characteristics that are influencing stem cell commitment, in order to develop a suitable engineered tissue for cardiac and skeletal muscle repair and a bio-actuator.
KW - Bio-actuator
KW - Bio-mechanical properties
KW - Cell sheet
KW - Mouse embryonic fibroblasts (MEF)
KW - Mouse skeletal myoblast
KW - Skeletal tensile test
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U2 - 10.2174/1874070702115010012
DO - 10.2174/1874070702115010012
M3 - Article
AN - SCOPUS:85101739444
SN - 1874-0707
VL - 15
SP - 12
EP - 18
JO - Open Biotechnology Journal
JF - Open Biotechnology Journal
IS - 1
ER -