Mechanically adaptive nanocomposites for neural interfacing

Jeffrey R. Capadona, Dustin J. Tyler, Christian A. Zorman, Stuart J. Rowan, Christoph Weder

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The recording of neural signals with microelectrodes that are implanted into the cortex of the brain is potentially useful for a range of clinical applications. However, the widespread use of such neural interfaces has so far been stifled because existing intracortical electrode systems rarely allow for consistent long-term recording of neural activity. This limitation is usually attributed to scar formation and neuron death near the surface of the implanted electrode. It has been proposed that the mechanical property mismatch between existing electrode materials and the brain tissue is a significant contributor to these events. To alleviate this problem, we utilized the architecture of the sea cucumber dermis as a blueprint to engineer a new class of mechanically adaptive materials as substrates for â œsmartâ intracortical electrodes. We demonstrated that these originally rigid polymer nanocomposites soften considerably upon exposure to emulated physiological and in vivo conditions. The adaptive nature of these bioinspired materials makes them useful as a basis for electrodes that are sufficiently stiff to be easily implanted and subsequently soften to better match the stiffness of the brain. Initial histological evaluations suggest that mechanically adaptive neural prosthetics can more rapidly stabilize neural cell populations at the device interface than rigid systems, which bodes well for improving the functionality of intracortical devices.

Original languageEnglish
Pages (from-to)581-589
Number of pages9
JournalMRS Bulletin
Volume37
Issue number6
DOIs
Publication statusPublished - 2012 Jun
Externally publishedYes

Fingerprint

brain
Nanocomposites
nanocomposites
Electrodes
electrodes
Brain
recording
blueprints
scars
cortexes
electrode materials
neurons
death
engineers
stiffness
Blueprints
mechanical properties
Microelectrodes
Prosthetics
evaluation

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Cite this

Capadona, J. R., Tyler, D. J., Zorman, C. A., Rowan, S. J., & Weder, C. (2012). Mechanically adaptive nanocomposites for neural interfacing. MRS Bulletin, 37(6), 581-589. https://doi.org/10.1557/mrs.2012.97

Mechanically adaptive nanocomposites for neural interfacing. / Capadona, Jeffrey R.; Tyler, Dustin J.; Zorman, Christian A.; Rowan, Stuart J.; Weder, Christoph.

In: MRS Bulletin, Vol. 37, No. 6, 06.2012, p. 581-589.

Research output: Contribution to journalArticle

Capadona, JR, Tyler, DJ, Zorman, CA, Rowan, SJ & Weder, C 2012, 'Mechanically adaptive nanocomposites for neural interfacing', MRS Bulletin, vol. 37, no. 6, pp. 581-589. https://doi.org/10.1557/mrs.2012.97
Capadona JR, Tyler DJ, Zorman CA, Rowan SJ, Weder C. Mechanically adaptive nanocomposites for neural interfacing. MRS Bulletin. 2012 Jun;37(6):581-589. https://doi.org/10.1557/mrs.2012.97
Capadona, Jeffrey R. ; Tyler, Dustin J. ; Zorman, Christian A. ; Rowan, Stuart J. ; Weder, Christoph. / Mechanically adaptive nanocomposites for neural interfacing. In: MRS Bulletin. 2012 ; Vol. 37, No. 6. pp. 581-589.
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