Abstract
Objective. The mechanisms underlying intracortical microelectrode encapsulation and failure are not well understood. A leading hypothesis implicates the role of the mechanical mismatch between rigid implant materials and the much softer brain tissue. Previous work has established the benefits of compliant materials on reducing early neuroinflammatory events. However, recent studies established late onset of a disease-like neurodegenerative state. Approach. In this study, we implanted mechanically-adaptive materials, which are initially rigid but become compliant after implantation, to investigate the long-term chronic neuroinflammatory response to compliant intracortical microelectrodes. Main results. Three days after implantation, during the acute healing phase of the response, the tissue response to the compliant implants was statistically similar to that of chemically matched stiff implants with much higher rigidity. However, at two, eight, and sixteen weeks post-implantation in the rat cortex, the compliant implants demonstrated a significantly reduced neuroinflammatory response when compared to stiff reference materials. Chronically implanted compliant materials also exhibited a more stable blood-brain barrier than the stiff reference materials. Significance. Overall, the data show strikingly that mechanically-compliant intracortical implants can reduce the neuroinflammatory response in comparison to stiffer systems.
| Original language | English |
|---|---|
| Article number | 056014 |
| Journal | Journal of Neural Engineering |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2014 Oct 1 |
| Externally published | Yes |
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Keywords
- biomimetic material
- foreign body response
- intracortical microelectrode
- mechanical properties
- nanocomposite
ASJC Scopus subject areas
- Biomedical Engineering
- Cellular and Molecular Neuroscience
- Medicine(all)
Cite this
Mechanically-compliant intracortical implants reduce the neuroinflammatory response. / Nguyen, Jessica K.; Park, Daniel J.; Skousen, John L.; Hess-Dunning, Allison E.; Tyler, Dustin J.; Rowan, Stuart J.; Weder, Christoph; Capadona, Jeffrey R.
In: Journal of Neural Engineering, Vol. 11, No. 5, 056014, 01.10.2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanically-compliant intracortical implants reduce the neuroinflammatory response
AU - Nguyen, Jessica K.
AU - Park, Daniel J.
AU - Skousen, John L.
AU - Hess-Dunning, Allison E.
AU - Tyler, Dustin J.
AU - Rowan, Stuart J.
AU - Weder, Christoph
AU - Capadona, Jeffrey R.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Objective. The mechanisms underlying intracortical microelectrode encapsulation and failure are not well understood. A leading hypothesis implicates the role of the mechanical mismatch between rigid implant materials and the much softer brain tissue. Previous work has established the benefits of compliant materials on reducing early neuroinflammatory events. However, recent studies established late onset of a disease-like neurodegenerative state. Approach. In this study, we implanted mechanically-adaptive materials, which are initially rigid but become compliant after implantation, to investigate the long-term chronic neuroinflammatory response to compliant intracortical microelectrodes. Main results. Three days after implantation, during the acute healing phase of the response, the tissue response to the compliant implants was statistically similar to that of chemically matched stiff implants with much higher rigidity. However, at two, eight, and sixteen weeks post-implantation in the rat cortex, the compliant implants demonstrated a significantly reduced neuroinflammatory response when compared to stiff reference materials. Chronically implanted compliant materials also exhibited a more stable blood-brain barrier than the stiff reference materials. Significance. Overall, the data show strikingly that mechanically-compliant intracortical implants can reduce the neuroinflammatory response in comparison to stiffer systems.
AB - Objective. The mechanisms underlying intracortical microelectrode encapsulation and failure are not well understood. A leading hypothesis implicates the role of the mechanical mismatch between rigid implant materials and the much softer brain tissue. Previous work has established the benefits of compliant materials on reducing early neuroinflammatory events. However, recent studies established late onset of a disease-like neurodegenerative state. Approach. In this study, we implanted mechanically-adaptive materials, which are initially rigid but become compliant after implantation, to investigate the long-term chronic neuroinflammatory response to compliant intracortical microelectrodes. Main results. Three days after implantation, during the acute healing phase of the response, the tissue response to the compliant implants was statistically similar to that of chemically matched stiff implants with much higher rigidity. However, at two, eight, and sixteen weeks post-implantation in the rat cortex, the compliant implants demonstrated a significantly reduced neuroinflammatory response when compared to stiff reference materials. Chronically implanted compliant materials also exhibited a more stable blood-brain barrier than the stiff reference materials. Significance. Overall, the data show strikingly that mechanically-compliant intracortical implants can reduce the neuroinflammatory response in comparison to stiffer systems.
KW - biomimetic material
KW - foreign body response
KW - intracortical microelectrode
KW - mechanical properties
KW - nanocomposite
UR - http://www.scopus.com/inward/record.url?scp=84907909025&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907909025&partnerID=8YFLogxK
U2 - 10.1088/1741-2560/11/5/056014
DO - 10.1088/1741-2560/11/5/056014
M3 - Article
C2 - 25125443
AN - SCOPUS:84907909025
VL - 11
JO - Journal of Neural Engineering
JF - Journal of Neural Engineering
SN - 1741-2560
IS - 5
M1 - 056014
ER -