Mechanically-compliant intracortical implants reduce the neuroinflammatory response

Jessica K. Nguyen, Daniel J. Park, John L. Skousen, Allison E. Hess-Dunning, Dustin J. Tyler, Stuart J. Rowan, Christoph Weder, Jeffrey R. Capadona

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Objective. The mechanisms underlying intracortical microelectrode encapsulation and failure are not well understood. A leading hypothesis implicates the role of the mechanical mismatch between rigid implant materials and the much softer brain tissue. Previous work has established the benefits of compliant materials on reducing early neuroinflammatory events. However, recent studies established late onset of a disease-like neurodegenerative state. Approach. In this study, we implanted mechanically-adaptive materials, which are initially rigid but become compliant after implantation, to investigate the long-term chronic neuroinflammatory response to compliant intracortical microelectrodes. Main results. Three days after implantation, during the acute healing phase of the response, the tissue response to the compliant implants was statistically similar to that of chemically matched stiff implants with much higher rigidity. However, at two, eight, and sixteen weeks post-implantation in the rat cortex, the compliant implants demonstrated a significantly reduced neuroinflammatory response when compared to stiff reference materials. Chronically implanted compliant materials also exhibited a more stable blood-brain barrier than the stiff reference materials. Significance. Overall, the data show strikingly that mechanically-compliant intracortical implants can reduce the neuroinflammatory response in comparison to stiffer systems.

Original languageEnglish
Article number056014
JournalJournal of Neural Engineering
Volume11
Issue number5
DOIs
Publication statusPublished - 2014 Oct 1
Externally publishedYes

Fingerprint

Microelectrodes
Acute-Phase Reaction
Blood-Brain Barrier
Brain
Tissue
Encapsulation
Rigidity
Rats
Late Onset Disorders

Keywords

  • biomimetic material
  • foreign body response
  • intracortical microelectrode
  • mechanical properties
  • nanocomposite

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Nguyen, J. K., Park, D. J., Skousen, J. L., Hess-Dunning, A. E., Tyler, D. J., Rowan, S. J., ... Capadona, J. R. (2014). Mechanically-compliant intracortical implants reduce the neuroinflammatory response. Journal of Neural Engineering, 11(5), [056014]. https://doi.org/10.1088/1741-2560/11/5/056014

Mechanically-compliant intracortical implants reduce the neuroinflammatory response. / Nguyen, Jessica K.; Park, Daniel J.; Skousen, John L.; Hess-Dunning, Allison E.; Tyler, Dustin J.; Rowan, Stuart J.; Weder, Christoph; Capadona, Jeffrey R.

In: Journal of Neural Engineering, Vol. 11, No. 5, 056014, 01.10.2014.

Research output: Contribution to journalArticle

Nguyen, JK, Park, DJ, Skousen, JL, Hess-Dunning, AE, Tyler, DJ, Rowan, SJ, Weder, C & Capadona, JR 2014, 'Mechanically-compliant intracortical implants reduce the neuroinflammatory response', Journal of Neural Engineering, vol. 11, no. 5, 056014. https://doi.org/10.1088/1741-2560/11/5/056014
Nguyen JK, Park DJ, Skousen JL, Hess-Dunning AE, Tyler DJ, Rowan SJ et al. Mechanically-compliant intracortical implants reduce the neuroinflammatory response. Journal of Neural Engineering. 2014 Oct 1;11(5). 056014. https://doi.org/10.1088/1741-2560/11/5/056014
Nguyen, Jessica K. ; Park, Daniel J. ; Skousen, John L. ; Hess-Dunning, Allison E. ; Tyler, Dustin J. ; Rowan, Stuart J. ; Weder, Christoph ; Capadona, Jeffrey R. / Mechanically-compliant intracortical implants reduce the neuroinflammatory response. In: Journal of Neural Engineering. 2014 ; Vol. 11, No. 5.
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