Mechanism of a transient but long-lasting immune memory function on a self/non-self boundary

Kouji Harada, Norio Shiratori

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Our previous study proposed an immune network model with evolving dynamics for antigen-specificity of a lymphocyte receptor, and obtained the following results: 1) the model revealed threshold dynamics to determine an immunological self/non-self boundary, and furthermore 2) the application of the threshold dynamics enabled an immune memory function. However, as the model equations were high- dimensional and nonlinear, the study could not explicate a mechanism for these immunological phenomena by analyzing the model equations. This study proposes a "minimal and analyzable" model that enables the reproduction of these two immunological phenomena. From analyses of isoclines of the model equations, 1) the threshold dynamics stems from the so-called excitable dynamics that are well-known in the firing dynamics of the neuron, and 2) the immune memory is realized not as a stable dynamical attractor, but as a long-lasting transient. This result indicates the possibility of a new type of immune memory different from the known dynamic attractor immune memory.

    Original languageEnglish
    Pages (from-to)519-525
    Number of pages7
    JournalUnknown Journal
    Volume2774 PART 2
    Publication statusPublished - 2003

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    Data storage equipment
    thresholds
    Lymphocytes
    lymphocytes
    antigens
    Antigens
    neurons
    stems
    Neurons

    ASJC Scopus subject areas

    • Hardware and Architecture

    Cite this

    Mechanism of a transient but long-lasting immune memory function on a self/non-self boundary. / Harada, Kouji; Shiratori, Norio.

    In: Unknown Journal, Vol. 2774 PART 2, 2003, p. 519-525.

    Research output: Contribution to journalArticle

    Harada, Kouji ; Shiratori, Norio. / Mechanism of a transient but long-lasting immune memory function on a self/non-self boundary. In: Unknown Journal. 2003 ; Vol. 2774 PART 2. pp. 519-525.
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