Mechanism of specific influence of L-Glutamic acid on the shape of L-Valine crystals

Hiromu Yoshiura, Hiroshi Nagano, Izumi Hirasawa

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    The specific interaction between L-valine (L-Val) and L-glutamic acid (L-Glu) in the process of evaporative crystallization from an aqueous solution has been investigated. It was found that only 2.0% (wt/wt) of L-Glu against the total amount of L-Val was required to induce significant agglomeration of L-Val. Interestingly, the agglomeration was only induced under acidic conditions, suggesting that the electrostatic interaction was an effective factor for the agglomeration process. As well as the electrostatic interaction, the length of the amino acid side chain was identified as another important factor. In addition, we confirmed that the incorporation rate of L-Glu into L-Val crystals was different during the nucleation and crystal growth stages. Based on these results, a mechanism has been proposed for the interaction of L-Glu and L-Val during the agglomeration process.

    Original languageEnglish
    Pages (from-to)55-60
    Number of pages6
    JournalJournal of Crystal Growth
    Volume363
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    glutamic acid
    Valine
    agglomeration
    Glutamic Acid
    Agglomeration
    Crystals
    Acids
    Crystallization
    Coulomb interactions
    crystals
    interactions
    electrostatics
    Crystal growth
    amino acids
    Amino acids
    crystal growth
    Nucleation
    nucleation
    crystallization
    aqueous solutions

    Keywords

    • A1. Biocrystallization
    • A1. Crystal morphology
    • A1. Crystal structure
    • A1. Impurities

    ASJC Scopus subject areas

    • Condensed Matter Physics
    • Materials Chemistry
    • Inorganic Chemistry

    Cite this

    Mechanism of specific influence of L-Glutamic acid on the shape of L-Valine crystals. / Yoshiura, Hiromu; Nagano, Hiroshi; Hirasawa, Izumi.

    In: Journal of Crystal Growth, Vol. 363, 2013, p. 55-60.

    Research output: Contribution to journalArticle

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    abstract = "The specific interaction between L-valine (L-Val) and L-glutamic acid (L-Glu) in the process of evaporative crystallization from an aqueous solution has been investigated. It was found that only 2.0{\%} (wt/wt) of L-Glu against the total amount of L-Val was required to induce significant agglomeration of L-Val. Interestingly, the agglomeration was only induced under acidic conditions, suggesting that the electrostatic interaction was an effective factor for the agglomeration process. As well as the electrostatic interaction, the length of the amino acid side chain was identified as another important factor. In addition, we confirmed that the incorporation rate of L-Glu into L-Val crystals was different during the nucleation and crystal growth stages. Based on these results, a mechanism has been proposed for the interaction of L-Glu and L-Val during the agglomeration process.",
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    N2 - The specific interaction between L-valine (L-Val) and L-glutamic acid (L-Glu) in the process of evaporative crystallization from an aqueous solution has been investigated. It was found that only 2.0% (wt/wt) of L-Glu against the total amount of L-Val was required to induce significant agglomeration of L-Val. Interestingly, the agglomeration was only induced under acidic conditions, suggesting that the electrostatic interaction was an effective factor for the agglomeration process. As well as the electrostatic interaction, the length of the amino acid side chain was identified as another important factor. In addition, we confirmed that the incorporation rate of L-Glu into L-Val crystals was different during the nucleation and crystal growth stages. Based on these results, a mechanism has been proposed for the interaction of L-Glu and L-Val during the agglomeration process.

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