TY - JOUR
T1 - Medical image-based hemodynamic analysis for modified blalock-taussig shunt
AU - Liu, Jinlong
AU - Sun, Qi
AU - Hong, Haifa
AU - Sun, Yanjun
AU - Liu, Jinfen
AU - Qian, Yi
AU - Wang, Qian
AU - Umezu, Mitsuo
N1 - Funding Information:
The authors wish to thank Prof. Y. Qian for many fruitful discussions and suggestions arisen during the preparation of this work. This work was supported by the National Nature Science Foundation of China (No. 81070133. P.I.: Jinfen Liu and No. 81100117. P.I.: Qi Sun), Project funded by China Postdoctoral Science Foundation (No. 2013M530200. P.I.: Jinlong Liu), Specialized Research Fund for the Doctoral Program of Higher Education of China (No. 20100073120088. P.I.: Qi Sun), Research Fund for Young Scholar of Shanghai Health Bureau (No. 2010Y162. P.I.: Qi Sun), Medicine-Engineering Project of Shanghai Jiao Tong University (No. YG2011MS55. P.I.: Qi Sun), Fund for Excellent Young Teachers in Shanghai Colleges and Universities (No. jyd10030. P.I.: Qi Sun), and the fund of The Shanghai Committee of Science and Technology (No. 134119a3900. P.I.: Yanjun Sun).
Publisher Copyright:
© 2015 World Scientific Publishing Company.
PY - 2015/6/19
Y1 - 2015/6/19
N2 - Modified Blalock-Taussig (mB-T) shunt is an effective palliative surgical method in the treatment of cyanotic congenital heart diseases. Although the surgical technique has improved over the years, it is still a challenge to control appropriate blood flow through the conduit. The formation of thrombosis in the conduit after the mB-T shunt may lead to severe desaturation or reoperation in some cases. Here, we applied the method of computational fluid dynamics (CFD) to study a patient-specific case based on medical images after the mB-T shunt. The real-time velocities derived from echocardiography and the pulsatile pressure waves measured during the operation were utilized as boundary conditions to physiologically capture the blood flow information in simulation. The calculated results were coincident with clinical measurements. Local pressure, blood flow distribution, streamlines, wall shear stress (WSS) and centrifugal force in the bended conduit were investigated. The results indicate that pressure decreases greatly through the conduit. The combined action of pulsatile pressure and WSS may lead to the damage of blood cells. The computational hemodynamics can be applied in future studies of establishing quantitative standards to evaluate surgical outcomes of the mB-T shunt.
AB - Modified Blalock-Taussig (mB-T) shunt is an effective palliative surgical method in the treatment of cyanotic congenital heart diseases. Although the surgical technique has improved over the years, it is still a challenge to control appropriate blood flow through the conduit. The formation of thrombosis in the conduit after the mB-T shunt may lead to severe desaturation or reoperation in some cases. Here, we applied the method of computational fluid dynamics (CFD) to study a patient-specific case based on medical images after the mB-T shunt. The real-time velocities derived from echocardiography and the pulsatile pressure waves measured during the operation were utilized as boundary conditions to physiologically capture the blood flow information in simulation. The calculated results were coincident with clinical measurements. Local pressure, blood flow distribution, streamlines, wall shear stress (WSS) and centrifugal force in the bended conduit were investigated. The results indicate that pressure decreases greatly through the conduit. The combined action of pulsatile pressure and WSS may lead to the damage of blood cells. The computational hemodynamics can be applied in future studies of establishing quantitative standards to evaluate surgical outcomes of the mB-T shunt.
KW - Modified Blalock-Taussig shunt
KW - cardiovascular flow
KW - computational fluid dynamics
KW - congenital heart disease
KW - hemodynamics
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U2 - 10.1142/S0219519415500359
DO - 10.1142/S0219519415500359
M3 - Article
AN - SCOPUS:84931331374
VL - 15
JO - Journal of Mechanics in Medicine and Biology
JF - Journal of Mechanics in Medicine and Biology
SN - 0219-5194
IS - 3
M1 - 1550035
ER -