Medical image-based hemodynamic analysis for modified blalock-taussig shunt

Jinlong Liu, Qi Sun, Haifa Hong, Yanjun Sun, Jinfen Liu, Yi Qian, Qian Wang, Mitsuo Umezu

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Modified Blalock-Taussig (mB-T) shunt is an effective palliative surgical method in the treatment of cyanotic congenital heart diseases. Although the surgical technique has improved over the years, it is still a challenge to control appropriate blood flow through the conduit. The formation of thrombosis in the conduit after the mB-T shunt may lead to severe desaturation or reoperation in some cases. Here, we applied the method of computational fluid dynamics (CFD) to study a patient-specific case based on medical images after the mB-T shunt. The real-time velocities derived from echocardiography and the pulsatile pressure waves measured during the operation were utilized as boundary conditions to physiologically capture the blood flow information in simulation. The calculated results were coincident with clinical measurements. Local pressure, blood flow distribution, streamlines, wall shear stress (WSS) and centrifugal force in the bended conduit were investigated. The results indicate that pressure decreases greatly through the conduit. The combined action of pulsatile pressure and WSS may lead to the damage of blood cells. The computational hemodynamics can be applied in future studies of establishing quantitative standards to evaluate surgical outcomes of the mB-T shunt.

    Original languageEnglish
    Article number1550035
    JournalJournal of Mechanics in Medicine and Biology
    Volume15
    Issue number3
    DOIs
    Publication statusPublished - 2015 Jun 19

    Fingerprint

    Hemodynamics
    Blood
    Shear stress
    Echocardiography
    Blood pressure
    Computational fluid dynamics
    Cells
    Boundary conditions

    Keywords

    • cardiovascular flow
    • computational fluid dynamics
    • congenital heart disease
    • hemodynamics
    • Modified Blalock-Taussig shunt

    ASJC Scopus subject areas

    • Biomedical Engineering

    Cite this

    Medical image-based hemodynamic analysis for modified blalock-taussig shunt. / Liu, Jinlong; Sun, Qi; Hong, Haifa; Sun, Yanjun; Liu, Jinfen; Qian, Yi; Wang, Qian; Umezu, Mitsuo.

    In: Journal of Mechanics in Medicine and Biology, Vol. 15, No. 3, 1550035, 19.06.2015.

    Research output: Contribution to journalArticle

    Liu, Jinlong ; Sun, Qi ; Hong, Haifa ; Sun, Yanjun ; Liu, Jinfen ; Qian, Yi ; Wang, Qian ; Umezu, Mitsuo. / Medical image-based hemodynamic analysis for modified blalock-taussig shunt. In: Journal of Mechanics in Medicine and Biology. 2015 ; Vol. 15, No. 3.
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