MEG Tomography of Human Cortex and Brainstem Activity in Waking and REM Sleep Saccades

Andreas A. Ioannides, Maria Corsi-Cabrera, Peter B C Fenwick, Yolanda Del Rio Portilla, Nikos A. Laskaris, Ara Khurshudyan, Dionyssios Theofilou, Tadahiko Shibata, Sunao Uchida, Tetsuo Nakabayashi, George K. Kostopoulos

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

We recorded the magnetoencephalographic (MEG) signal from three subjects before, during and after eye movements cued to a tone, self-paced, awake and during rapid eye movement (REM) sleep. During sleep we recorded the MEG signal throughout the night together with electroencephalographic (EEG) and electromyographic (EMG) channels to construct a hypnogram. While awake, just prior to and during eye movements, the expected well time-locked physiological activations were imaged in pontine regions, with early 3 s priming. Activity in the frontal eye fields (FEF) was identified in the 300 ms before the saccade onset. Visual cortex activation occurred 200 ms after saccades. During REM, compared to the eyes closed awake condition, activity was higher in supplementary motor area (SMA) and lower in inferior parietal and precuneus cortex. Electroocculographic (EOG) activity just prior to REM saccades correlated with bilateral pontine and FEF activity some 250-400 ms before REM saccade onset, which in turn was preceded 200 ms earlier by reciprocal activation of the pons and FEF. An orbitofrontal-amygdalo-parahippocampal-pontine sequence, possibly related to emotional activation during REM sleep, was identified in the last 100 ms leading to the REM saccade, but not linked to saccade initiation.

Original languageEnglish
Pages (from-to)56-72
Number of pages17
JournalCerebral Cortex
Volume14
Issue number1
DOIs
Publication statusPublished - 2004 Jan
Externally publishedYes

Fingerprint

Saccades
REM Sleep
Brain Stem
Sleep
Tomography
Frontal Lobe
Parietal Lobe
Eye Movements
Pons
Motor Cortex
Visual Cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ioannides, A. A., Corsi-Cabrera, M., Fenwick, P. B. C., Del Rio Portilla, Y., Laskaris, N. A., Khurshudyan, A., ... Kostopoulos, G. K. (2004). MEG Tomography of Human Cortex and Brainstem Activity in Waking and REM Sleep Saccades. Cerebral Cortex, 14(1), 56-72. https://doi.org/10.1093/cercor/bhg091

MEG Tomography of Human Cortex and Brainstem Activity in Waking and REM Sleep Saccades. / Ioannides, Andreas A.; Corsi-Cabrera, Maria; Fenwick, Peter B C; Del Rio Portilla, Yolanda; Laskaris, Nikos A.; Khurshudyan, Ara; Theofilou, Dionyssios; Shibata, Tadahiko; Uchida, Sunao; Nakabayashi, Tetsuo; Kostopoulos, George K.

In: Cerebral Cortex, Vol. 14, No. 1, 01.2004, p. 56-72.

Research output: Contribution to journalArticle

Ioannides, AA, Corsi-Cabrera, M, Fenwick, PBC, Del Rio Portilla, Y, Laskaris, NA, Khurshudyan, A, Theofilou, D, Shibata, T, Uchida, S, Nakabayashi, T & Kostopoulos, GK 2004, 'MEG Tomography of Human Cortex and Brainstem Activity in Waking and REM Sleep Saccades', Cerebral Cortex, vol. 14, no. 1, pp. 56-72. https://doi.org/10.1093/cercor/bhg091
Ioannides AA, Corsi-Cabrera M, Fenwick PBC, Del Rio Portilla Y, Laskaris NA, Khurshudyan A et al. MEG Tomography of Human Cortex and Brainstem Activity in Waking and REM Sleep Saccades. Cerebral Cortex. 2004 Jan;14(1):56-72. https://doi.org/10.1093/cercor/bhg091
Ioannides, Andreas A. ; Corsi-Cabrera, Maria ; Fenwick, Peter B C ; Del Rio Portilla, Yolanda ; Laskaris, Nikos A. ; Khurshudyan, Ara ; Theofilou, Dionyssios ; Shibata, Tadahiko ; Uchida, Sunao ; Nakabayashi, Tetsuo ; Kostopoulos, George K. / MEG Tomography of Human Cortex and Brainstem Activity in Waking and REM Sleep Saccades. In: Cerebral Cortex. 2004 ; Vol. 14, No. 1. pp. 56-72.
@article{5de50f5ceb8e4a9589f38046bef8baf5,
title = "MEG Tomography of Human Cortex and Brainstem Activity in Waking and REM Sleep Saccades",
abstract = "We recorded the magnetoencephalographic (MEG) signal from three subjects before, during and after eye movements cued to a tone, self-paced, awake and during rapid eye movement (REM) sleep. During sleep we recorded the MEG signal throughout the night together with electroencephalographic (EEG) and electromyographic (EMG) channels to construct a hypnogram. While awake, just prior to and during eye movements, the expected well time-locked physiological activations were imaged in pontine regions, with early 3 s priming. Activity in the frontal eye fields (FEF) was identified in the 300 ms before the saccade onset. Visual cortex activation occurred 200 ms after saccades. During REM, compared to the eyes closed awake condition, activity was higher in supplementary motor area (SMA) and lower in inferior parietal and precuneus cortex. Electroocculographic (EOG) activity just prior to REM saccades correlated with bilateral pontine and FEF activity some 250-400 ms before REM saccade onset, which in turn was preceded 200 ms earlier by reciprocal activation of the pons and FEF. An orbitofrontal-amygdalo-parahippocampal-pontine sequence, possibly related to emotional activation during REM sleep, was identified in the last 100 ms leading to the REM saccade, but not linked to saccade initiation.",
author = "Ioannides, {Andreas A.} and Maria Corsi-Cabrera and Fenwick, {Peter B C} and {Del Rio Portilla}, Yolanda and Laskaris, {Nikos A.} and Ara Khurshudyan and Dionyssios Theofilou and Tadahiko Shibata and Sunao Uchida and Tetsuo Nakabayashi and Kostopoulos, {George K.}",
year = "2004",
month = "1",
doi = "10.1093/cercor/bhg091",
language = "English",
volume = "14",
pages = "56--72",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - MEG Tomography of Human Cortex and Brainstem Activity in Waking and REM Sleep Saccades

AU - Ioannides, Andreas A.

AU - Corsi-Cabrera, Maria

AU - Fenwick, Peter B C

AU - Del Rio Portilla, Yolanda

AU - Laskaris, Nikos A.

AU - Khurshudyan, Ara

AU - Theofilou, Dionyssios

AU - Shibata, Tadahiko

AU - Uchida, Sunao

AU - Nakabayashi, Tetsuo

AU - Kostopoulos, George K.

PY - 2004/1

Y1 - 2004/1

N2 - We recorded the magnetoencephalographic (MEG) signal from three subjects before, during and after eye movements cued to a tone, self-paced, awake and during rapid eye movement (REM) sleep. During sleep we recorded the MEG signal throughout the night together with electroencephalographic (EEG) and electromyographic (EMG) channels to construct a hypnogram. While awake, just prior to and during eye movements, the expected well time-locked physiological activations were imaged in pontine regions, with early 3 s priming. Activity in the frontal eye fields (FEF) was identified in the 300 ms before the saccade onset. Visual cortex activation occurred 200 ms after saccades. During REM, compared to the eyes closed awake condition, activity was higher in supplementary motor area (SMA) and lower in inferior parietal and precuneus cortex. Electroocculographic (EOG) activity just prior to REM saccades correlated with bilateral pontine and FEF activity some 250-400 ms before REM saccade onset, which in turn was preceded 200 ms earlier by reciprocal activation of the pons and FEF. An orbitofrontal-amygdalo-parahippocampal-pontine sequence, possibly related to emotional activation during REM sleep, was identified in the last 100 ms leading to the REM saccade, but not linked to saccade initiation.

AB - We recorded the magnetoencephalographic (MEG) signal from three subjects before, during and after eye movements cued to a tone, self-paced, awake and during rapid eye movement (REM) sleep. During sleep we recorded the MEG signal throughout the night together with electroencephalographic (EEG) and electromyographic (EMG) channels to construct a hypnogram. While awake, just prior to and during eye movements, the expected well time-locked physiological activations were imaged in pontine regions, with early 3 s priming. Activity in the frontal eye fields (FEF) was identified in the 300 ms before the saccade onset. Visual cortex activation occurred 200 ms after saccades. During REM, compared to the eyes closed awake condition, activity was higher in supplementary motor area (SMA) and lower in inferior parietal and precuneus cortex. Electroocculographic (EOG) activity just prior to REM saccades correlated with bilateral pontine and FEF activity some 250-400 ms before REM saccade onset, which in turn was preceded 200 ms earlier by reciprocal activation of the pons and FEF. An orbitofrontal-amygdalo-parahippocampal-pontine sequence, possibly related to emotional activation during REM sleep, was identified in the last 100 ms leading to the REM saccade, but not linked to saccade initiation.

UR - http://www.scopus.com/inward/record.url?scp=9144221444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9144221444&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhg091

DO - 10.1093/cercor/bhg091

M3 - Article

C2 - 14654457

AN - SCOPUS:9144221444

VL - 14

SP - 56

EP - 72

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 1

ER -