Melatonin modulates the light-induced sympathoexcitation and vagal suppression with participation of the suprachiasmatic nucleus in mice

Tatsushi Mutho, Shigenobu Shibata, Horst Werner Korf, Hitoshi Okamura

    Research output: Contribution to journalArticle

    48 Citations (Scopus)

    Abstract

    In mammals, the autonomic nervous system mediates the central circadian clock oscillation from the suprachiasmatic nucleus (SCN) to the peripheral organs, and controls cardiovascular, respiratory and gastrointestinal functions. The present study was conducted in mice to address whether light signals conveyed to the SCN can control peripheral autonomic functions, and further examined the impact of centrally administered melatonin on peripheral autonomic functions via activation of melatonin receptor signalling. In vivo electrophysiological techniques were performed in anaesthetised, open-chest and artificially ventilated mice whilst monitoring the arterial blood pressure and heart rate. Light induced an increase of the renal sympathetic nerve activity, arterial blood pressure and heart rate immediately after lights on. Conversely, light rapidly suppressed the gastric vagal parasympathetic nerve activity, which was affected neither by hepatic vagotomy nor by total subdiaphragmatic vagotomy. These autonomic responses were mediated by the SCN since bilateral SCN lesion totally abolished the light-evoked neuronal and cardiovascular responses. Melatonin administered intracerebroventricularly (I.C.V.) attenuated the sympathetic and vagal nerve activities in a dose-dependent manner with a threshold of 0.1 ng and these effects were blocked by I.C.V. pre-treatment of the competitive melatonin receptor antagonist luzindole. These results suggest that light induces sympathoexcitation and vagal suppression through the SCN and that melatonin modulates the light-induced autonomic responses via activation of the central melatonin receptor signalling.

    Original languageEnglish
    Pages (from-to)317-332
    Number of pages16
    JournalJournal of Physiology
    Volume547
    Issue number1
    DOIs
    Publication statusPublished - 2003 Feb 15

    Fingerprint

    Suprachiasmatic Nucleus
    Melatonin
    Light
    Melatonin Receptors
    Vagotomy
    Arterial Pressure
    Heart Rate
    Circadian Clocks
    Autonomic Nervous System
    Mammals
    Stomach
    Thorax
    Kidney
    Liver

    ASJC Scopus subject areas

    • Physiology

    Cite this

    Melatonin modulates the light-induced sympathoexcitation and vagal suppression with participation of the suprachiasmatic nucleus in mice. / Mutho, Tatsushi; Shibata, Shigenobu; Korf, Horst Werner; Okamura, Hitoshi.

    In: Journal of Physiology, Vol. 547, No. 1, 15.02.2003, p. 317-332.

    Research output: Contribution to journalArticle

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