Membrane fouling and dialysate flow pattern in an internal filtration-enhancing dialyzer

Ken Ichiro Yamamoto, Michihito Hiwatari, Fukashi Kohori, Kiyotaka Sakai, Makoto Fukuda, Tatsuo Hiyoshi

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    For efficient removal of large molecular weight solutes by dialysis, several types of internal filtration-enhancing dialyzers (IFEDs) are commercially available. However, in a pressure-driven membrane separation process (i.e., filtration), membrane fouling caused by adhesion of plasma proteins is a severe problem. The objective of the present study is to investigate the effects of internal filtration on membrane fouling based on the membrane's pure-water permeability, diffusive permeability, and sieving coefficient. Hemodialysis experiments were performed with two different dialyzers, IFEDs and non-IFEDs. Local membrane fouling in each dialyzer was evaluated by measuring the pure-water permeability, the diffusive permeability, and the sieving coefficient of native membranes and membranes treated with bovine blood. The effects of packing ratio on dialysate flow pattern were also evaluated by measuring the time required for an ion tracer to reach electrodes placed in the dialyzers. In the IFED, membrane fouling caused by protein adhesion is increased because of enhanced internal filtration only at the early stage of dialysis, and this fouling tends to occur only near the dialysate outlet port. However, enhanced internal filtration has little effect on measured membrane transfer parameters.

    Original languageEnglish
    Pages (from-to)198-205
    Number of pages8
    JournalJournal of Artificial Organs
    Volume8
    Issue number3
    DOIs
    Publication statusPublished - 2005 Sep

    Fingerprint

    Membrane fouling
    Dialysis Solutions
    Flow patterns
    Membranes
    Permeability
    Dialysis
    Adhesion
    Proteins
    Water
    Fouling
    Blood Proteins
    Blood
    Renal Dialysis
    Molecular weight
    Electrodes
    Ions
    Molecular Weight
    Plasmas
    Pressure

    Keywords

    • Dialysate flow pattern
    • Dialysis
    • Internal filtration
    • Internal filtration-enhancing dialyzer
    • Membrane fouling

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Membrane fouling and dialysate flow pattern in an internal filtration-enhancing dialyzer. / Yamamoto, Ken Ichiro; Hiwatari, Michihito; Kohori, Fukashi; Sakai, Kiyotaka; Fukuda, Makoto; Hiyoshi, Tatsuo.

    In: Journal of Artificial Organs, Vol. 8, No. 3, 09.2005, p. 198-205.

    Research output: Contribution to journalArticle

    Yamamoto, Ken Ichiro ; Hiwatari, Michihito ; Kohori, Fukashi ; Sakai, Kiyotaka ; Fukuda, Makoto ; Hiyoshi, Tatsuo. / Membrane fouling and dialysate flow pattern in an internal filtration-enhancing dialyzer. In: Journal of Artificial Organs. 2005 ; Vol. 8, No. 3. pp. 198-205.
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